DegronMD - O60749(SNX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R70I	TCGA-AX-A2HC	UCEC	TCGA	REDLFAE	LIG_APCC_ABBAyCdc20_2	70:76	Mutation altering degron motif	0.8102
p.R70I	DO41572	UCEC	ICGC	REDLFAE	LIG_APCC_ABBAyCdc20_2	70:76	Mutation altering degron motif	0.8102
p.E80D	TCGA-AZ-6608	COAD	TCGA	REDLFAE	LIG_APCC_ABBAyCdc20_2	70:76	Mutation rewiring degron network	0.2222
p.E80D	DO7954	COAD	ICGC	REDLFAE	LIG_APCC_ABBAyCdc20_2	70:76	Mutation rewiring degron network	0.2222
p.A75V	TCGA-F7-A624	HNSC	TCGA	REDLFAE	LIG_APCC_ABBAyCdc20_2	70:76	Mutation altering degron motif	0.5825
p.A75V	DO44440	HNSC	ICGC	REDLFAE	LIG_APCC_ABBAyCdc20_2	70:76	Mutation altering degron motif	0.5825
p.L83S	TCGA-GF-A4EO	SKCM	TCGA	REDLFAE	LIG_APCC_ABBAyCdc20_2	70:76	Mutation rewiring degron network	0.1389
p.L83S	DO47559	SKCM	ICGC	REDLFAE	LIG_APCC_ABBAyCdc20_2	70:76	Mutation rewiring degron network	0.1389
p.D69Y	DO50708	ORCA	ICGC	REDLFAE	LIG_APCC_ABBAyCdc20_2	70:76	Mutation rewiring degron network	0.3056
p.S82Y	SIDM00118	Colorectal Carcinoma	GDSC	REDLFAE	LIG_APCC_ABBAyCdc20_2	70:76	Mutation rewiring degron network	0.1667
p.S82Y	ACH-001081	Colon/Colorectal Cancer	CCLE	REDLFAE	LIG_APCC_ABBAyCdc20_2	70:76	Mutation rewiring degron network	0.1667
p.S82Y	HCC2998	large intestine	COSMIC	REDLFAE	LIG_APCC_ABBAyCdc20_2	70:76	Mutation rewiring degron network	0.1667
p.D69N	ACH-000883	Brain Cancer	CCLE	REDLFAE	LIG_APCC_ABBAyCdc20_2	70:76	Mutation rewiring degron network	0.3056
p.D69N	SW1783	central nervous system	COSMIC	REDLFAE	LIG_APCC_ABBAyCdc20_2	70:76	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons