DegronMD

Uniprot ID: O60749

Source protein: Sorting nexin-2

Source gene: SNX2

Class: LIG_APCC_ABBAyCdc20_2

Location: 70:76

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8951

ASA_SCORE: 93.4143

COIL: 0.456

CONS_SCORE: 0.3412

DSS_SCORE: 0.658

HELIX: 0.5261

FCONS_SCORE: 1.0846

RIG_SCORE: 0.7666

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R70I	TCGA-AX-A2HC	UCEC	TCGA	REDLFAE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R70I	DO41572	UCEC	ICGC	REDLFAE	LIG_APCC_ABBAyCdc20_2	0.8102
p.A75V	TCGA-F7-A624	HNSC	TCGA	REDLFAE	LIG_APCC_ABBAyCdc20_2	0.5825
p.A75V	DO44440	HNSC	ICGC	REDLFAE	LIG_APCC_ABBAyCdc20_2	0.5825
p.D69Y	DO50708	ORCA	ICGC	REDLFAE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D69N	ACH-000883	Brain Cancer	CCLE	REDLFAE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D69N	SW1783	central_nervous_system	COSMIC	REDLFAE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E80D	TCGA-AZ-6608	COAD	TCGA	REDLFAE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E80D	DO7954	COAD	ICGC	REDLFAE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S82Y	SIDM00118	Colorectal Carcinoma	GDSC	REDLFAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S82Y	ACH-001081	Colon/Colorectal Cancer	CCLE	REDLFAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S82Y	HCC2998	large_intestine	COSMIC	REDLFAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.L83S	TCGA-GF-A4EO	SKCM	TCGA	REDLFAE	LIG_APCC_ABBAyCdc20_2	0.1389
p.L83S	DO47559	SKCM	ICGC	REDLFAE	LIG_APCC_ABBAyCdc20_2	0.1389

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60749	Sorting nexin-2	LIG_APCC_ABBAyCdc20_2	70:76	REDLFAE	APC,CDC20,FZR1	0.8951	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons