DegronMD - O60840(CACNA1F)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R450C	TCGA-12-0826	GBM	TCGA	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.1667
p.E430A	TCGA-13-0794	OV	TCGA	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.1667
p.E430A	DO30660	OV	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.1667
p.E430K	TCGA-62-A46R	LUAD	TCGA	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.1667
p.E430K	DO45355	LUAD	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.1667
p.R433Q	TCGA-A2-A0YK	BRCA	TCGA	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.25
p.R433Q	DO2836	BRCA	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.25
p.A434V	TCGA-A6-5661	COAD	TCGA	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.2778
p.A434V	DO8634	COAD	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.2778
p.R452C	TCGA-DX-A1L2	SARC	TCGA	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.1111
p.R450H	TCGA-G4-6625	COAD	TCGA	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.1667
p.R439H	DO9266	COAD	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.8244
p.R439C	DO13929	GBM	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.8301
p.H436Y	DO228654	LICA	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.6118
p.R439S	DO229027	LICA	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.7427
p.R437S	DO229026	LICA	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.7427
p.G426V	DO27120	LUSC	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.0556
p.R441C	DO219951	SARC	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.8301
p.L429M	DO229211	THCA	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.1389
p.A430T	DO229211	THCA	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.1667
p.R448C	DO41020	UCEC	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.2222
p.R448C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.2222
p.R437W	SIDM00251	Gastric Carcinoma	GDSC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.8634
p.R437W	TGBC11TKB	stomach	COSMIC	HRPQLAELT	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.8634

Kaplan plot for CACNA1F in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CACNA1F

UniProt ID: O60840

Entrez ID: 778

Protein name: Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage-gated calcium channel subunit alpha Cav1.4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CACNA1F in