DegronMD

Uniprot ID: O60840

Source protein: Voltage-dependent L-type calcium channel subunit alpha-1F

Source gene: CACNA1F

Class: DEG_APCC_DBOX_1

Location: 436:444

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5751

ASA_SCORE: 77.1556

COIL: 0.4466

CONS_SCORE: 0.2674

DSS_SCORE: 0.6433

HELIX: 0.5052

FCONS_SCORE: 0.9983

RIG_SCORE: 0.717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R450C	TCGA-12-0826	GBM	TCGA	HRPQLAELT	DEG_APCC_DBOX_1	0.1667
p.E430A	TCGA-13-0794	OV	TCGA	HRPQLAELT	DEG_APCC_DBOX_1	0.1667
p.E430A	DO30660	OV	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	0.1667
p.E430K	TCGA-62-A46R	LUAD	TCGA	HRPQLAELT	DEG_APCC_DBOX_1	0.1667
p.E430K	DO45355	LUAD	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	0.1667
p.R433Q	TCGA-A2-A0YK	BRCA	TCGA	HRPQLAELT	DEG_APCC_DBOX_1	0.25
p.R433Q	DO2836	BRCA	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	0.25
p.A434V	TCGA-A6-5661	COAD	TCGA	HRPQLAELT	DEG_APCC_DBOX_1	0.2778
p.A434V	DO8634	COAD	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	0.2778
p.R452C	TCGA-DX-A1L2	SARC	TCGA	HRPQLAELT	DEG_APCC_DBOX_1	0.1111
p.R450H	TCGA-G4-6625	COAD	TCGA	HRPQLAELT	DEG_APCC_DBOX_1	0.1667
p.R439H	DO9266	COAD	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	0.8244
p.R439C	DO13929	GBM	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	0.8301
p.H436Y	DO228654	LICA	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	0.6118
p.R439S	DO229027	LICA	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	0.7427
p.R437S	DO229026	LICA	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	0.7427
p.G426V	DO27120	LUSC	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	0.0556
p.R441C	DO219951	SARC	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	0.8301
p.L429M	DO229211	THCA	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	0.1389
p.A430T	DO229211	THCA	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	0.1667
p.R448C	DO41020	UCEC	ICGC	HRPQLAELT	DEG_APCC_DBOX_1	0.2222
p.R448C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	HRPQLAELT	DEG_APCC_DBOX_1	0.2222
p.R437W	SIDM00251	Gastric Carcinoma	GDSC	HRPQLAELT	DEG_APCC_DBOX_1	0.8634
p.R437W	TGBC11TKB	stomach	COSMIC	HRPQLAELT	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	DEG_APCC_DBOX_1	436:444	HRPQLAELT	APC,CDC20,FZR1	0.5751	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons