DegronMD - O60841(EIF5B)

EIF5B

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q456K	TCGA-4Z-AA80	BLCA	TCGA	KRPIYED	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.1111
p.Q456K	DO218986	BLCA	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.1111
p.K450N	TCGA-67-3771	LUAD	TCGA	KRPIYED	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.2778
p.K450N	DO25797	LUAD	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.2778
p.K450N	SIDM02044	Colorectal Carcinoma	GDSC	KRPIYED	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.2778
p.E432D	TCGA-L5-A8NS	ESCA	TCGA	KRPIYED	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.0556
p.K453I	DO222798	COCA	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	442:448	Mutation substituting flanking lysine	0.3056
p.S438Y	DO222884	COCA	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	442:448	Mutation blocking phosphorylation signal	0.6667
p.K452E	DO233179	GACA	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	442:448	Mutation substituting flanking lysine	0.3333
p.P455Q	DO221122	MALY	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.1389
p.S438T	DO232761	PBCA	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	442:448	Mutation blocking phosphorylation signal	0.6667
p.K453E	DO47016	RECA	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	442:448	Mutation substituting flanking lysine	0.3056
p.R451K	DO229232	THCA	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.25
p.S435L	ACH-000975	Lung Cancer	CCLE	KRPIYED	LIG_APCC_ABBAyCdc20_2	442:448	Mutation blocking phosphorylation signal	0.5833

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*NOTE: the Kaplan plots were collected from OncoLnc