DegronMD

Uniprot ID: O60841

Source protein: Eukaryotic translation initiation factor 5B

Source gene: EIF5B

Class: LIG_APCC_ABBAyCdc20_2

Location: 442:448

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9984

ASA_SCORE: 112.9

COIL: 0.8447

CONS_SCORE: 0.3114

DSS_SCORE: 0.5604

HELIX: 0.12

FCONS_SCORE: 1.1439

RIG_SCORE: 0.7404

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q456K	TCGA-4Z-AA80	BLCA	TCGA	KRPIYED	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q456K	DO218986	BLCA	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	0.1111
p.K450N	TCGA-67-3771	LUAD	TCGA	KRPIYED	LIG_APCC_ABBAyCdc20_2	0.2778
p.K450N	DO25797	LUAD	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	0.2778
p.K450N	SIDM02044	Colorectal Carcinoma	GDSC	KRPIYED	LIG_APCC_ABBAyCdc20_2	0.2778
p.E432D	TCGA-L5-A8NS	ESCA	TCGA	KRPIYED	LIG_APCC_ABBAyCdc20_2	0.0556
p.K453I	DO222798	COCA	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	0.3056
p.S438Y	DO222884	COCA	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	0.6667
p.K452E	DO233179	GACA	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	0.3333
p.P455Q	DO221122	MALY	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	0.1389
p.S438T	DO232761	PBCA	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	0.6667
p.K453E	DO47016	RECA	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	0.3056
p.R451K	DO229232	THCA	ICGC	KRPIYED	LIG_APCC_ABBAyCdc20_2	0.25
p.S435L	ACH-000975	Lung Cancer	CCLE	KRPIYED	LIG_APCC_ABBAyCdc20_2	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60841	Eukaryotic translation initiation factor 5B	LIG_APCC_ABBAyCdc20_2	442:448	KRPIYED	APC,CDC20,FZR1	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons