DegronMD - O75054(IGSF3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1041N	TCGA-4Z-AA7M	BLCA	TCGA	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.2222
p.D1041N	DO218976	BLCA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.2222
p.D1040E	DO222490	BTCA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.25
p.D1040E	DO222571	COCA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.25
p.D1040E	DO222737	COCA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.25
p.D1040E	DO229016	COCA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.25
p.D1040E	DO233652	GACA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.25
p.D1040E	DO233869	GACA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.25
p.E1028D	DO234362	ESAD	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.3056
p.E1039D	DO233737	GACA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.2778
p.E1039D	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.2778
p.E1039D	SIDM00889	Cervical Carcinoma	GDSC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.2778
p.E1039D	SIDM00878	Breast Carcinoma	GDSC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.2778
p.D1041E	DO218180	ORCA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.2222
p.D1043N	SIDM01293	Colorectal Carcinoma	GDSC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.1667
p.D1042E	SIDM00706	Small Cell Lung Carcinoma	GDSC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.1944
p.D1041V	SIDM00628	Breast Carcinoma	GDSC	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.2222
p.P1024H	ACH-001719	Ovarian Cancer	CCLE	ERTALLSVG	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.1944

Kaplan plot for IGSF3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGSF3

UniProt ID: O75054

Entrez ID: 3321

Protein name: Immunoglobulin superfamily member 3 (IgSF3) (Glu-Trp-Ile EWI motif-containing protein 3) (EWI-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGSF3 in