DegronMD

Uniprot ID: O75054

Source protein: Immunoglobulin superfamily member 3

Source gene: IGSF3

Class: DEG_APCC_DBOX_1

Location: 1029:1037

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8225

ASA_SCORE: 39.2444

COIL: 0.262

CONS_SCORE: 0.5258

DSS_SCORE: 0.7618

HELIX: 0.0142

FCONS_SCORE: 1.4292

RIG_SCORE: 0.7079

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1041N	TCGA-4Z-AA7M	BLCA	TCGA	ERTALLSVG	DEG_APCC_DBOX_1	0.2222
p.D1041N	DO218976	BLCA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	0.2222
p.D1040E	DO222490	BTCA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	0.25
p.D1040E	DO222571	COCA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	0.25
p.D1040E	DO222737	COCA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	0.25
p.D1040E	DO229016	COCA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	0.25
p.D1040E	DO233652	GACA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	0.25
p.D1040E	DO233869	GACA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	0.25
p.E1028D	DO234362	ESAD	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	0.3056
p.E1039D	DO233737	GACA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	0.2778
p.E1039D	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	ERTALLSVG	DEG_APCC_DBOX_1	0.2778
p.E1039D	SIDM00889	Cervical Carcinoma	GDSC	ERTALLSVG	DEG_APCC_DBOX_1	0.2778
p.E1039D	SIDM00878	Breast Carcinoma	GDSC	ERTALLSVG	DEG_APCC_DBOX_1	0.2778
p.D1041E	DO218180	ORCA	ICGC	ERTALLSVG	DEG_APCC_DBOX_1	0.2222
p.D1043N	SIDM01293	Colorectal Carcinoma	GDSC	ERTALLSVG	DEG_APCC_DBOX_1	0.1667
p.D1042E	SIDM00706	Small Cell Lung Carcinoma	GDSC	ERTALLSVG	DEG_APCC_DBOX_1	0.1944
p.D1041V	SIDM00628	Breast Carcinoma	GDSC	ERTALLSVG	DEG_APCC_DBOX_1	0.2222
p.P1024H	ACH-001719	Ovarian Cancer	CCLE	ERTALLSVG	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75054	Immunoglobulin superfamily member 3	DEG_APCC_DBOX_1	1029:1037	ERTALLSVG	APC,CDC20,FZR1	0.8225	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons