DegronMD - O75161(NPHP4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R923H	TCGA-AD-A5EJ	COAD	TCGA	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.25
p.R923H	DO50090	COAD	ICGC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.25
p.S921F	TCGA-DR-A0ZL	CESC	TCGA	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.3056
p.S921F	DO6344	CESC	ICGC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.3056
p.G928E	TCGA-EB-A24D	SKCM	TCGA	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1111
p.G928E	DO37440	SKCM	ICGC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1111
p.R918Q	DO233072	GACA	ICGC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.6218
p.R906H	DO50979	LAML	ICGC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1667
p.R906H	SIDM00680	Colorectal Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1667
p.R906H	SIDM00308	Chronic Myelogenous Leukemia	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1667
p.R906H	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1667
p.R906H	SIDM00054	Pancreatic Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1667
p.R906H	SIDM00302	Other Solid Cancers	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1667
p.R906H	SIDM00381	Cervical Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1667
p.R906H	SIDM01511	Gastric Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1667
p.R906H	SIDM01451	Pancreatic Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1667
p.A927T	DO50970	LICA	ICGC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1389
p.K915R	DO229216	THCA	ICGC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.6126
p.R912H	SIDM02013	Colorectal Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.7133
p.R918W	SIDM00596	Endometrial Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.7523
p.R918W	ACH-001517	Endometrial/Uterine Cancer	CCLE	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.7523
p.R918W	HEC-1	endometrium	COSMIC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.7523
p.R914H	SIDM01321	Pancreatic Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.7133
p.R914H	ACH-000307	Pancreatic Cancer	CCLE	RRRKLERMR	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.7133

Kaplan plot for NPHP4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NPHP4

UniProt ID: O75161

Entrez ID: 261734

Protein name: Nephrocystin-4 (Nephroretinin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NPHP4 in