DegronMD

Uniprot ID: O75161

Source protein: Nephrocystin-4

Source gene: NPHP4

Class: DEG_APCC_DBOX_1

Location: 912:920

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.986

ASA_SCORE: 102.3111

COIL: 0.0536

CONS_SCORE: 0.4537

DSS_SCORE: 0.5987

HELIX: 0.9468

FCONS_SCORE: 1.1995

RIG_SCORE: 0.7536

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R923H	TCGA-AD-A5EJ	COAD	TCGA	RRRKLERMR	DEG_APCC_DBOX_1	0.25
p.R923H	DO50090	COAD	ICGC	RRRKLERMR	DEG_APCC_DBOX_1	0.25
p.S921F	TCGA-DR-A0ZL	CESC	TCGA	RRRKLERMR	DEG_APCC_DBOX_1	0.3056
p.S921F	DO6344	CESC	ICGC	RRRKLERMR	DEG_APCC_DBOX_1	0.3056
p.G928E	TCGA-EB-A24D	SKCM	TCGA	RRRKLERMR	DEG_APCC_DBOX_1	0.1111
p.G928E	DO37440	SKCM	ICGC	RRRKLERMR	DEG_APCC_DBOX_1	0.1111
p.R918Q	DO233072	GACA	ICGC	RRRKLERMR	DEG_APCC_DBOX_1	0.6218
p.R906H	DO50979	LAML	ICGC	RRRKLERMR	DEG_APCC_DBOX_1	0.1667
p.R906H	SIDM00680	Colorectal Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	0.1667
p.R906H	SIDM00308	Chronic Myelogenous Leukemia	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	0.1667
p.R906H	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	0.1667
p.R906H	SIDM00054	Pancreatic Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	0.1667
p.R906H	SIDM00302	Other Solid Cancers	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	0.1667
p.R906H	SIDM00381	Cervical Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	0.1667
p.R906H	SIDM01511	Gastric Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	0.1667
p.R906H	SIDM01451	Pancreatic Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	0.1667
p.A927T	DO50970	LICA	ICGC	RRRKLERMR	DEG_APCC_DBOX_1	0.1389
p.K915R	DO229216	THCA	ICGC	RRRKLERMR	DEG_APCC_DBOX_1	0.6126
p.R912H	SIDM02013	Colorectal Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	0.7133
p.R918W	SIDM00596	Endometrial Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	0.7523
p.R918W	ACH-001517	Endometrial/Uterine Cancer	CCLE	RRRKLERMR	DEG_APCC_DBOX_1	0.7523
p.R918W	HEC-1	endometrium	COSMIC	RRRKLERMR	DEG_APCC_DBOX_1	0.7523
p.R914H	SIDM01321	Pancreatic Carcinoma	GDSC	RRRKLERMR	DEG_APCC_DBOX_1	0.7133
p.R914H	ACH-000307	Pancreatic Cancer	CCLE	RRRKLERMR	DEG_APCC_DBOX_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75161	Nephrocystin-4	DEG_APCC_DBOX_1	912:920	RRRKLERMR	APC,CDC20,FZR1	0.986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRKLERMR

Degron related mutations and impact score

Drug responses associated with NPHP4 mutations

All proteins holding degron of RRRKLERMR