DegronMD - O75164(KDM4A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R597H	TCGA-2W-A8YY	CESC	TCGA	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation altering degron motif	0.8244
p.R597H	TCGA-AX-A05Z	UCEC	TCGA	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation altering degron motif	0.8244
p.R597H	TCGA-FI-A2D5	UCEC	TCGA	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation altering degron motif	0.8244
p.R597H	DO223732	CESC	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation altering degron motif	0.8244
p.R597H	DO40884	UCEC	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation altering degron motif	0.8244
p.R597H	DO41331	UCEC	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation altering degron motif	0.8244
p.R597S	TCGA-BF-A1PU	SKCM	TCGA	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation altering degron motif	0.7427
p.R597S	DO50278	SKCM	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation altering degron motif	0.7427
p.L587I	TCGA-D3-A2JC	SKCM	TCGA	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation rewiring degron network	0.0833
p.L587I	DO47578	SKCM	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation rewiring degron network	0.0833
p.R605H	TCGA-IB-7651	PAAD	TCGA	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation rewiring degron network	0.3056
p.R605H	TCGA-VQ-A8P2	STAD	TCGA	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation rewiring degron network	0.3056
p.R605H	DO46657	PAAD	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation rewiring degron network	0.3056
p.R605H	DO51761	STAD	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation rewiring degron network	0.3056
p.V610L	DO228948	LICA	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation rewiring degron network	0.1667
p.L603P	DO229499	SKCA	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation altering degron motif	0.7582
p.Q612K	SIDM00993	Plasma Cell Myeloma	GDSC	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation rewiring degron network	0.1111
p.Q612K	ACH-000838	Myeloma	CCLE	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation rewiring degron network	0.1111
p.Q612K	AMO-1	haematopoietic and lymphoid tissue	COSMIC	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation rewiring degron network	0.1111
p.P599S	SIDM00301	Pancreatic Carcinoma	GDSC	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation altering degron motif	0.5641
p.P599S	ACH-000265	Pancreatic Cancer	CCLE	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation altering degron motif	0.5641
p.P599S	KP-4	pancreas	COSMIC	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation altering degron motif	0.5641
p.L609F	ACH-002396	Bone Cancer	CCLE	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation rewiring degron network	0.1944
p.L609F	Sarc9371	bone	COSMIC	RRQPLSKLP	DEG_APCC_DBOX_1	596:604	Mutation rewiring degron network	0.1944

Kaplan plot for KDM4A in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KDM4A

UniProt ID: O75164

Entrez ID: 9682

Protein name: Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KDM4A in