DegronMD

Uniprot ID: O75164

Source protein: Lysine-specific demethylase 4A

Source gene: KDM4A

Class: DEG_APCC_DBOX_1

Location: 596:604

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9754

ASA_SCORE: 111.1778

COIL: 0.9221

CONS_SCORE: 0.3364

DSS_SCORE: 0.5896

HELIX: 0.0343

FCONS_SCORE: 1.0427

RIG_SCORE: 0.6209

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R597H	TCGA-2W-A8YY	CESC	TCGA	RRQPLSKLP	DEG_APCC_DBOX_1	0.8244
p.R597H	TCGA-AX-A05Z	UCEC	TCGA	RRQPLSKLP	DEG_APCC_DBOX_1	0.8244
p.R597H	TCGA-FI-A2D5	UCEC	TCGA	RRQPLSKLP	DEG_APCC_DBOX_1	0.8244
p.R597H	DO223732	CESC	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	0.8244
p.R597H	DO40884	UCEC	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	0.8244
p.R597H	DO41331	UCEC	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	0.8244
p.R597S	TCGA-BF-A1PU	SKCM	TCGA	RRQPLSKLP	DEG_APCC_DBOX_1	0.7427
p.R597S	DO50278	SKCM	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	0.7427
p.L587I	TCGA-D3-A2JC	SKCM	TCGA	RRQPLSKLP	DEG_APCC_DBOX_1	0.0833
p.L587I	DO47578	SKCM	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	0.0833
p.R605H	TCGA-IB-7651	PAAD	TCGA	RRQPLSKLP	DEG_APCC_DBOX_1	0.3056
p.R605H	TCGA-VQ-A8P2	STAD	TCGA	RRQPLSKLP	DEG_APCC_DBOX_1	0.3056
p.R605H	DO46657	PAAD	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	0.3056
p.R605H	DO51761	STAD	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	0.3056
p.V610L	DO228948	LICA	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	0.1667
p.L603P	DO229499	SKCA	ICGC	RRQPLSKLP	DEG_APCC_DBOX_1	0.7582
p.Q612K	SIDM00993	Plasma Cell Myeloma	GDSC	RRQPLSKLP	DEG_APCC_DBOX_1	0.1111
p.Q612K	ACH-000838	Myeloma	CCLE	RRQPLSKLP	DEG_APCC_DBOX_1	0.1111
p.Q612K	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	RRQPLSKLP	DEG_APCC_DBOX_1	0.1111
p.P599S	SIDM00301	Pancreatic Carcinoma	GDSC	RRQPLSKLP	DEG_APCC_DBOX_1	0.5641
p.P599S	ACH-000265	Pancreatic Cancer	CCLE	RRQPLSKLP	DEG_APCC_DBOX_1	0.5641
p.P599S	KP-4	pancreas	COSMIC	RRQPLSKLP	DEG_APCC_DBOX_1	0.5641
p.L609F	ACH-002396	Bone Cancer	CCLE	RRQPLSKLP	DEG_APCC_DBOX_1	0.1944
p.L609F	Sarc9371	bone	COSMIC	RRQPLSKLP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75164	Lysine-specific demethylase 4A	DEG_APCC_DBOX_1	596:604	RRQPLSKLP	APC,CDC20,FZR1	0.9754	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons