DegronMD - O75170(PPP6R2)

PPP6R2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M625I	TCGA-55-8620	LUAD	TCGA	IQPFDD	LIG_APCC_ABBA_1	627:632	Mutation rewiring degron network	0.2778
p.M624L	DO222973	BTCA	ICGC	IQPFDD	LIG_APCC_ABBA_1	627:632	Mutation rewiring degron network	0.25
p.G642C	DO229024	LICA	ICGC	IQPFDD	LIG_APCC_ABBA_1	627:632	Mutation rewiring degron network	0.0556
p.M624I	DO24547	LUAD	ICGC	IQPFDD	LIG_APCC_ABBA_1	627:632	Mutation rewiring degron network	0.25
p.F630Y	SIDM00362	Burkitt's Lymphoma	GDSC	IQPFDD	LIG_APCC_ABBA_1	627:632	Mutation altering degron motif	0.6417
p.F630Y	P32-ISH	haematopoietic and lymphoid tissue	COSMIC	IQPFDD	LIG_APCC_ABBA_1	627:632	Mutation altering degron motif	0.6417
p.R618C	ACH-000693	Esophageal Cancer	CCLE	IQPFDD	LIG_APCC_ABBA_1	627:632	Mutation rewiring degron network	0.0833
p.R618C	KYSE-180	oesophagus	COSMIC	IQPFDD	LIG_APCC_ABBA_1	627:632	Mutation rewiring degron network	0.0833
p.K640N	ACH-000783	Breast Cancer	CCLE	IQPFDD	LIG_APCC_ABBA_1	627:632	Mutation rewiring degron network	0.1111
p.K640N	CAMA-1	breast	COSMIC	IQPFDD	LIG_APCC_ABBA_1	627:632	Mutation rewiring degron network	0.1111
p.R619C	KYSE-180	oesophagus	COSMIC	IQPFDD	LIG_APCC_ABBA_1	627:632	Mutation rewiring degron network	0.1111
p.K641N	CAMA-1	breast	COSMIC	IQPFDD	LIG_APCC_ABBA_1	627:632	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc