DegronMD

Uniprot ID: O75170

Source protein: Serine/threonine-protein phosphatase 6 regulatory subunit 2

Source gene: PPP6R2

Class: LIG_APCC_ABBA_1

Location: 627:632

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8923

ASA_SCORE: 84.1167

COIL: 0.8578

CONS_SCORE: 0.2974

DSS_SCORE: 0.4653

HELIX: 0.0792

FCONS_SCORE: 0.8392

RIG_SCORE: 0.7446

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M625I	TCGA-55-8620	LUAD	TCGA	IQPFDD	LIG_APCC_ABBA_1	0.2778
p.M624L	DO222973	BTCA	ICGC	IQPFDD	LIG_APCC_ABBA_1	0.25
p.G642C	DO229024	LICA	ICGC	IQPFDD	LIG_APCC_ABBA_1	0.0556
p.M624I	DO24547	LUAD	ICGC	IQPFDD	LIG_APCC_ABBA_1	0.25
p.F630Y	SIDM00362	Burkitt's Lymphoma	GDSC	IQPFDD	LIG_APCC_ABBA_1	0.6417
p.F630Y	P32-ISH	haematopoietic_and_lymphoid_tissue	COSMIC	IQPFDD	LIG_APCC_ABBA_1	0.6417
p.R618C	ACH-000693	Esophageal Cancer	CCLE	IQPFDD	LIG_APCC_ABBA_1	0.0833
p.R618C	KYSE-180	oesophagus	COSMIC	IQPFDD	LIG_APCC_ABBA_1	0.0833
p.K640N	ACH-000783	Breast Cancer	CCLE	IQPFDD	LIG_APCC_ABBA_1	0.1111
p.K640N	CAMA-1	breast	COSMIC	IQPFDD	LIG_APCC_ABBA_1	0.1111
p.R619C	KYSE-180	oesophagus	COSMIC	IQPFDD	LIG_APCC_ABBA_1	0.1111
p.K641N	CAMA-1	breast	COSMIC	IQPFDD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75170	Serine/threonine-protein phosphatase 6 regulatory subunit 2	LIG_APCC_ABBA_1	627:632	IQPFDD	APC,CDC20,FZR1	0.8923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons