DegronMD - O75173(ADAMTS4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A822S	TCGA-AJ-A3EK	UCEC	TCGA	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.0833
p.A822S	DO41584	UCEC	ICGC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.0833
p.H819Y	TCGA-D5-6928	COAD	TCGA	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.1667
p.H819Y	DO7776	COAD	ICGC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.1667
p.R811H	TCGA-KL-8337	KICH	TCGA	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation altering degron motif	0.7133
p.R811H	DO220345	KICH	ICGC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation altering degron motif	0.7133
p.Q823E	TCGA-NC-A5HN	LUSC	TCGA	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.0556
p.Q823E	DO52025	LUSC	ICGC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.0556
p.R797P	TCGA-NH-A50V	COAD	TCGA	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.0556
p.R797P	DO44094	COAD	ICGC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.0556
p.R820Q	DO228190	LICA	ICGC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.1389
p.D816N	SIDM00683	Prostate Carcinoma	GDSC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.25
p.D816N	ACH-000977	lymph node	CCLE	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.25
p.D816N	LNCaP-Clone-FGC	prostate	COSMIC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.25
p.R804W	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.25
p.R804W	ACH-000795	Leukemia	CCLE	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.25
p.R804W	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.25
p.P803T	SIDM00193	Colorectal Carcinoma	GDSC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.2222
p.P803T	ACH-000991	Colon/Colorectal Cancer	CCLE	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.2222
p.P803T	SNU-81	large intestine	COSMIC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.2222
p.P807H	SIDM01113	Other Sarcomas	GDSC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation altering degron motif	0.7694
p.P807H	ACH-000939	Sarcoma	CCLE	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation altering degron motif	0.7694
p.P807H	SK-UT-1	soft tissue	COSMIC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation altering degron motif	0.7694
p.R797Q	SIDM00596	Endometrial Carcinoma	GDSC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.0556
p.R797Q	ACH-000179	Lung Cancer	CCLE	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.0556
p.R797Q	ACH-000941	Endometrial/Uterine Cancer	CCLE	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.0556
p.R797Q	ACH-000954	Endometrial/Uterine Cancer	CCLE	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.0556
p.R797Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.0556
p.R797Q	HEC-1	endometrium	COSMIC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation rewiring degron network	0.0556
p.T809M	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation altering degron motif	0.7423
p.T809M	SIDM01664	Prostate Carcinoma	GDSC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation altering degron motif	0.7423
p.T809M	SIDM01739	Small Cell Lung Carcinoma	GDSC	PSTPRPT	DEG_SCF_FBW7_1	807:813	Mutation altering degron motif	0.7423

Kaplan plot for ADAMTS4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAMTS4

UniProt ID: O75173

Entrez ID: 9507

Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAMTS4 in