DegronMD

Uniprot ID: O75173

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 4

Source gene: ADAMTS4

Class: DEG_SCF_FBW7_1

Location: 807:813

E3 ligase: FBXW7

DEGRON score: 0.6592

ASA_SCORE: 87.8857

COIL: 0.9139

CONS_SCORE: 0.8903

DSS_SCORE: 0.5872

HELIX: 0.018

FCONS_SCORE: 1.0243

RIG_SCORE: 0.6124

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A822S	TCGA-AJ-A3EK	UCEC	TCGA	PSTPRPT	DEG_SCF_FBW7_1	0.0833
p.A822S	DO41584	UCEC	ICGC	PSTPRPT	DEG_SCF_FBW7_1	0.0833
p.H819Y	TCGA-D5-6928	COAD	TCGA	PSTPRPT	DEG_SCF_FBW7_1	0.1667
p.H819Y	DO7776	COAD	ICGC	PSTPRPT	DEG_SCF_FBW7_1	0.1667
p.R811H	TCGA-KL-8337	KICH	TCGA	PSTPRPT	DEG_SCF_FBW7_1	0.7133
p.R811H	DO220345	KICH	ICGC	PSTPRPT	DEG_SCF_FBW7_1	0.7133
p.Q823E	TCGA-NC-A5HN	LUSC	TCGA	PSTPRPT	DEG_SCF_FBW7_1	0.0556
p.Q823E	DO52025	LUSC	ICGC	PSTPRPT	DEG_SCF_FBW7_1	0.0556
p.R797P	TCGA-NH-A50V	COAD	TCGA	PSTPRPT	DEG_SCF_FBW7_1	0.0556
p.R797P	DO44094	COAD	ICGC	PSTPRPT	DEG_SCF_FBW7_1	0.0556
p.R820Q	DO228190	LICA	ICGC	PSTPRPT	DEG_SCF_FBW7_1	0.1389
p.D816N	SIDM00683	Prostate Carcinoma	GDSC	PSTPRPT	DEG_SCF_FBW7_1	0.25
p.D816N	ACH-000977	lymph_node	CCLE	PSTPRPT	DEG_SCF_FBW7_1	0.25
p.D816N	LNCaP-Clone-FGC	prostate	COSMIC	PSTPRPT	DEG_SCF_FBW7_1	0.25
p.R804W	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PSTPRPT	DEG_SCF_FBW7_1	0.25
p.R804W	ACH-000795	Leukemia	CCLE	PSTPRPT	DEG_SCF_FBW7_1	0.25
p.R804W	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPRPT	DEG_SCF_FBW7_1	0.25
p.P803T	SIDM00193	Colorectal Carcinoma	GDSC	PSTPRPT	DEG_SCF_FBW7_1	0.2222
p.P803T	ACH-000991	Colon/Colorectal Cancer	CCLE	PSTPRPT	DEG_SCF_FBW7_1	0.2222
p.P803T	SNU-81	large_intestine	COSMIC	PSTPRPT	DEG_SCF_FBW7_1	0.2222
p.P807H	SIDM01113	Other Sarcomas	GDSC	PSTPRPT	DEG_SCF_FBW7_1	0.7694
p.P807H	ACH-000939	Sarcoma	CCLE	PSTPRPT	DEG_SCF_FBW7_1	0.7694
p.P807H	SK-UT-1	soft_tissue	COSMIC	PSTPRPT	DEG_SCF_FBW7_1	0.7694
p.R797Q	SIDM00596	Endometrial Carcinoma	GDSC	PSTPRPT	DEG_SCF_FBW7_1	0.0556
p.R797Q	ACH-000179	Lung Cancer	CCLE	PSTPRPT	DEG_SCF_FBW7_1	0.0556
p.R797Q	ACH-000941	Endometrial/Uterine Cancer	CCLE	PSTPRPT	DEG_SCF_FBW7_1	0.0556
p.R797Q	ACH-000954	Endometrial/Uterine Cancer	CCLE	PSTPRPT	DEG_SCF_FBW7_1	0.0556
p.R797Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	PSTPRPT	DEG_SCF_FBW7_1	0.0556
p.R797Q	HEC-1	endometrium	COSMIC	PSTPRPT	DEG_SCF_FBW7_1	0.0556
p.T809M	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	PSTPRPT	DEG_SCF_FBW7_1	0.7423
p.T809M	SIDM01664	Prostate Carcinoma	GDSC	PSTPRPT	DEG_SCF_FBW7_1	0.7423
p.T809M	SIDM01739	Small Cell Lung Carcinoma	GDSC	PSTPRPT	DEG_SCF_FBW7_1	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTPRPT

Degron related mutations and impact score

Drug responses associated with ADAMTS4 mutations

All proteins holding degron of PSTPRPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75173	A disintegrin and metalloproteinase with thrombospondin motifs 4	DEG_SCF_FBW7_1	807:813	PSTPRPT	FBXW7	0.6592	More...