DegronMD - O75306(NDUFS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R35W	TCGA-AN-A046	BRCA	TCGA	IQPSRGVR	SCF_FBXL2	28:35	Mutation altering degron motif	0.8634
p.R35W	DO1285	BRCA	ICGC	IQPSRGVR	SCF_FBXL2	28:35	Mutation altering degron motif	0.8634
p.G21A	TCGA-CR-6472	HNSC	TCGA	IQPSRGVR	SCF_FBXL2	28:35	Mutation rewiring degron network	0.1389
p.G21A	DO15870	HNSC	ICGC	IQPSRGVR	SCF_FBXL2	28:35	Mutation rewiring degron network	0.1389
p.R35Q	TCGA-CV-A6K1	HNSC	TCGA	IQPSRGVR	SCF_FBXL2	28:35	Mutation altering degron motif	0.7329
p.R35Q	DO52078	HNSC	ICGC	IQPSRGVR	SCF_FBXL2	28:35	Mutation altering degron motif	0.7329
p.R35Q	SIDM01018	Hodgkin's Lymphoma	GDSC	IQPSRGVR	SCF_FBXL2	28:35	Mutation altering degron motif	0.7329
p.R35Q	ACH-000815	Lymphoma	CCLE	IQPSRGVR	SCF_FBXL2	28:35	Mutation altering degron motif	0.7329
p.R35Q	KM-H2	haematopoietic and lymphoid tissue	COSMIC	IQPSRGVR	SCF_FBXL2	28:35	Mutation altering degron motif	0.7329
p.Q36H	TCGA-PK-A5HB	ACC	TCGA	IQPSRGVR	SCF_FBXL2	28:35	Mutation rewiring degron network	0.3056
p.D40H	TCGA-XF-AAMG	BLCA	TCGA	IQPSRGVR	SCF_FBXL2	28:35	Mutation rewiring degron network	0.1944
p.D40H	DO219049	BLCA	ICGC	IQPSRGVR	SCF_FBXL2	28:35	Mutation rewiring degron network	0.1944
p.R19W	DO229010	COCA	ICGC	IQPSRGVR	SCF_FBXL2	28:35	Mutation rewiring degron network	0.0833
p.P20T	DO229005	COCA	ICGC	IQPSRGVR	SCF_FBXL2	28:35	Mutation rewiring degron network	0.1111
p.P20T	DO230659	LAML	ICGC	IQPSRGVR	SCF_FBXL2	28:35	Mutation rewiring degron network	0.1111
p.P20T	DO229047	LICA	ICGC	IQPSRGVR	SCF_FBXL2	28:35	Mutation rewiring degron network	0.1111
p.P20T	DO231124	LUSC	ICGC	IQPSRGVR	SCF_FBXL2	28:35	Mutation rewiring degron network	0.1111
p.Q38H	DO228971	LICA	ICGC	IQPSRGVR	SCF_FBXL2	28:35	Mutation rewiring degron network	0.25
p.L18M	DO229227	THCA	ICGC	IQPSRGVR	SCF_FBXL2	28:35	Mutation rewiring degron network	0.0556

Kaplan plot for NDUFS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NDUFS2

UniProt ID: O75306

Entrez ID: 4720

Protein name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 7.1.1.2) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NDUFS2 in