DegronMD

Uniprot ID: O75306

Source protein: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

Source gene: NDUFS2

Class: SCF_FBXL2

Location: 28:35

E3 ligase: FBXL2

DEGRON score: 0.9508

ASA_SCORE: 80.925

COIL: 0.8791

CONS_SCORE: 0.2632

DSS_SCORE: 0.3714

HELIX: 0.0393

FCONS_SCORE: 0.9863

RIG_SCORE: 0.7413

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R35W	TCGA-AN-A046	BRCA	TCGA	IQPSRGVR	SCF_FBXL2	0.8634
p.R35W	DO1285	BRCA	ICGC	IQPSRGVR	SCF_FBXL2	0.8634
p.G21A	TCGA-CR-6472	HNSC	TCGA	IQPSRGVR	SCF_FBXL2	0.1389
p.G21A	DO15870	HNSC	ICGC	IQPSRGVR	SCF_FBXL2	0.1389
p.R35Q	TCGA-CV-A6K1	HNSC	TCGA	IQPSRGVR	SCF_FBXL2	0.7329
p.R35Q	DO52078	HNSC	ICGC	IQPSRGVR	SCF_FBXL2	0.7329
p.R35Q	SIDM01018	Hodgkin's Lymphoma	GDSC	IQPSRGVR	SCF_FBXL2	0.7329
p.R35Q	ACH-000815	Lymphoma	CCLE	IQPSRGVR	SCF_FBXL2	0.7329
p.R35Q	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	IQPSRGVR	SCF_FBXL2	0.7329
p.Q36H	TCGA-PK-A5HB	ACC	TCGA	IQPSRGVR	SCF_FBXL2	0.3056
p.D40H	TCGA-XF-AAMG	BLCA	TCGA	IQPSRGVR	SCF_FBXL2	0.1944
p.D40H	DO219049	BLCA	ICGC	IQPSRGVR	SCF_FBXL2	0.1944
p.R19W	DO229010	COCA	ICGC	IQPSRGVR	SCF_FBXL2	0.0833
p.P20T	DO229005	COCA	ICGC	IQPSRGVR	SCF_FBXL2	0.1111
p.P20T	DO230659	LAML	ICGC	IQPSRGVR	SCF_FBXL2	0.1111
p.P20T	DO229047	LICA	ICGC	IQPSRGVR	SCF_FBXL2	0.1111
p.P20T	DO231124	LUSC	ICGC	IQPSRGVR	SCF_FBXL2	0.1111
p.Q38H	DO228971	LICA	ICGC	IQPSRGVR	SCF_FBXL2	0.25
p.L18M	DO229227	THCA	ICGC	IQPSRGVR	SCF_FBXL2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75306	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	SCF_FBXL2	28:35	IQPSRGVR	FBXL2	0.9508	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons