DegronMD - O75319(DUSP11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R298Q	TCGA-AP-A0LM	UCEC	TCGA	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.1667
p.R298Q	TCGA-CA-6717	COAD	TCGA	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.1667
p.R298Q	DO8264	COAD	ICGC	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.1667
p.R298Q	DO43306	UCEC	ICGC	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.1667
p.Q290H	TCGA-UY-A78K	BLCA	TCGA	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.647
p.Q290H	DO219031	BLCA	ICGC	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.647
p.P279A	DO52576	BOCA	ICGC	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.1944
p.Q290P	DO222884	COCA	ICGC	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.5924
p.Q292L	DO228278	LICA	ICGC	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.6654
p.A296V	SIDM00672	Hepatocellular Carcinoma	GDSC	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.2222
p.A296V	SIDM00068	Colorectal Carcinoma	GDSC	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.2222
p.A296V	SIDM01525	Acute Myeloid Leukemia	GDSC	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation rewiring degron network	0.2222
p.H289R	SIDM00934	Pancreatic Carcinoma	GDSC	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.7133
p.H289R	ACH-000354	Pancreatic Cancer	CCLE	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.7133
p.H289R	CAPAN-1	pancreas	COSMIC	PRYNLHQIQ	DEG_APCC_DBOX_1	284:292	Mutation altering degron motif	0.7133

Kaplan plot for DUSP11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DUSP11

UniProt ID: O75319

Entrez ID: 8446

Protein name: RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Dual specificity protein phosphatase 11) (Phosphatase that interacts with RNA/RNP complex 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DUSP11 in