DegronMD

Uniprot ID: O75319

Source protein: RNA/RNP complex-1-interacting phosphatase

Source gene: DUSP11

Class: DEG_APCC_DBOX_1

Location: 284:292

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8488

ASA_SCORE: 104.9111

COIL: 0.8492

CONS_SCORE: 0.1427

DSS_SCORE: 0.7249

HELIX: 0.1144

FCONS_SCORE: 0.8113

RIG_SCORE: 0.6627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R298Q	TCGA-AP-A0LM	UCEC	TCGA	PRYNLHQIQ	DEG_APCC_DBOX_1	0.1667
p.R298Q	TCGA-CA-6717	COAD	TCGA	PRYNLHQIQ	DEG_APCC_DBOX_1	0.1667
p.R298Q	DO8264	COAD	ICGC	PRYNLHQIQ	DEG_APCC_DBOX_1	0.1667
p.R298Q	DO43306	UCEC	ICGC	PRYNLHQIQ	DEG_APCC_DBOX_1	0.1667
p.Q290H	TCGA-UY-A78K	BLCA	TCGA	PRYNLHQIQ	DEG_APCC_DBOX_1	0.647
p.Q290H	DO219031	BLCA	ICGC	PRYNLHQIQ	DEG_APCC_DBOX_1	0.647
p.P279A	DO52576	BOCA	ICGC	PRYNLHQIQ	DEG_APCC_DBOX_1	0.1944
p.Q290P	DO222884	COCA	ICGC	PRYNLHQIQ	DEG_APCC_DBOX_1	0.5924
p.Q292L	DO228278	LICA	ICGC	PRYNLHQIQ	DEG_APCC_DBOX_1	0.6654
p.A296V	SIDM00672	Hepatocellular Carcinoma	GDSC	PRYNLHQIQ	DEG_APCC_DBOX_1	0.2222
p.A296V	SIDM00068	Colorectal Carcinoma	GDSC	PRYNLHQIQ	DEG_APCC_DBOX_1	0.2222
p.A296V	SIDM01525	Acute Myeloid Leukemia	GDSC	PRYNLHQIQ	DEG_APCC_DBOX_1	0.2222
p.H289R	SIDM00934	Pancreatic Carcinoma	GDSC	PRYNLHQIQ	DEG_APCC_DBOX_1	0.7133
p.H289R	ACH-000354	Pancreatic Cancer	CCLE	PRYNLHQIQ	DEG_APCC_DBOX_1	0.7133
p.H289R	CAPAN-1	pancreas	COSMIC	PRYNLHQIQ	DEG_APCC_DBOX_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75319	RNA/RNP complex-1-interacting phosphatase	DEG_APCC_DBOX_1	284:292	PRYNLHQIQ	APC,CDC20,FZR1	0.8488	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons