DegronMD - O75325(LRRN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S46Y	TCGA-44-2668	LUAD	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.712
p.S46Y	DO25232	LUAD	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.712
p.R48C	TCGA-52-7810	LUSC	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.2778
p.R48C	DO27381	LUSC	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.2778
p.C29S	TCGA-86-6851	LUAD	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.0556
p.C29S	DO23798	LUAD	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.0556
p.R44H	TCGA-AX-A2HD	UCEC	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.7133
p.R44H	DO42608	UCEC	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.7133
p.T42M	TCGA-B5-A3FC	UCEC	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.7423
p.T42M	TCGA-EY-A1G8	UCEC	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.7423
p.T42M	DO43578	UCEC	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.7423
p.T42M	DO41871	UCEC	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.7423
p.D54Y	TCGA-BD-A2L6	LIHC	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.1111
p.D54Y	DO219551	LIHC	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.1111
p.Q32R	TCGA-BK-A13B	UCEC	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.1389
p.Q32R	DO40825	UCEC	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.1389
p.E49A	TCGA-ER-A193	SKCM	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.25
p.E49A	DO47368	SKCM	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.25
p.E49D	DO233091	GACA	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.25
p.P43H	DO228952	LICA	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.7694
p.P31H	DO229544	UTCA	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.1111
p.C35Y	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.2222
p.C35Y	ACH-000917	Esophageal Cancer	CCLE	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.2222
p.C35Y	TE-4	oesophagus	COSMIC	PWYTPRSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.2222

Kaplan plot for LRRN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRN2

UniProt ID: O75325

Entrez ID: 10446

Protein name: Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRN2 in