DegronMD

Uniprot ID: O75325

Source protein: Leucine-rich repeat neuronal protein 2

Source gene: LRRN2

Class: DEG_SCF_FBW7_1

Location: 39:46

E3 ligase: FBXW7

DEGRON score: 0.6964

ASA_SCORE: 78.1125

COIL: 0.7344

CONS_SCORE: 0.4257

DSS_SCORE: 0.161

HELIX: 0.0736

FCONS_SCORE: 0.837

RIG_SCORE: 0.8108

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S46Y	TCGA-44-2668	LUAD	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	0.712
p.S46Y	DO25232	LUAD	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	0.712
p.R48C	TCGA-52-7810	LUSC	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	0.2778
p.R48C	DO27381	LUSC	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	0.2778
p.C29S	TCGA-86-6851	LUAD	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	0.0556
p.C29S	DO23798	LUAD	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	0.0556
p.R44H	TCGA-AX-A2HD	UCEC	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	0.7133
p.R44H	DO42608	UCEC	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	0.7133
p.T42M	TCGA-B5-A3FC	UCEC	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	0.7423
p.T42M	TCGA-EY-A1G8	UCEC	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	0.7423
p.T42M	DO43578	UCEC	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	0.7423
p.T42M	DO41871	UCEC	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	0.7423
p.D54Y	TCGA-BD-A2L6	LIHC	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	0.1111
p.D54Y	DO219551	LIHC	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	0.1111
p.Q32R	TCGA-BK-A13B	UCEC	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	0.1389
p.Q32R	DO40825	UCEC	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	0.1389
p.E49A	TCGA-ER-A193	SKCM	TCGA	PWYTPRSS	DEG_SCF_FBW7_1	0.25
p.E49A	DO47368	SKCM	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	0.25
p.E49D	DO233091	GACA	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	0.25
p.P43H	DO228952	LICA	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	0.7694
p.P31H	DO229544	UTCA	ICGC	PWYTPRSS	DEG_SCF_FBW7_1	0.1111
p.C35Y	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PWYTPRSS	DEG_SCF_FBW7_1	0.2222
p.C35Y	ACH-000917	Esophageal Cancer	CCLE	PWYTPRSS	DEG_SCF_FBW7_1	0.2222
p.C35Y	TE-4	oesophagus	COSMIC	PWYTPRSS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75325	Leucine-rich repeat neuronal protein 2	DEG_SCF_FBW7_1	39:46	PWYTPRSS	FBXW7	0.6964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons