DegronMD - O75335(PPFIA4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H687Y	TCGA-BH-A0AZ	BRCA	TCGA	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.25
p.T667I	DO45205	LIRI	ICGC	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.0833
p.R685L	DO26200	LUAD	ICGC	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.3056
p.R685W	DO220886	MELA	ICGC	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.3056
p.R689Q	DO37719	SKCM	ICGC	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.1944
p.R689Q	H513	pleura	COSMIC	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.1944
p.M666I	DO41752	UCEC	ICGC	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.0556
p.P669L	DO41235	UCEC	ICGC	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.1389
p.R690Q	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.1667
p.R690Q	H513	pleura	COSMIC	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.1667
p.L673I	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.25
p.L673I	ACH-000875	Lung Cancer	CCLE	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.25
p.L673I	NCI-H2347	lung	COSMIC	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.25
p.H676R	SIDM01706	Hodgkin's Lymphoma	GDSC	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation altering degron motif	0.8244
p.H676R	ACH-001093	Non-Cancerous	CCLE	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation altering degron motif	0.8244
p.E688K	SIDM01640	Acute Myeloid Leukemia	GDSC	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.2222
p.E688K	ACH-000602	Leukemia	CCLE	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.2222
p.L672I	NCI-H2347	lung	COSMIC	RRKLLSPVS	DEG_APCC_DBOX_1	676:684	Mutation rewiring degron network	0.2222

Kaplan plot for PPFIA4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPFIA4

UniProt ID: O75335

Entrez ID: 8497

Protein name: Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPFIA4 in