DegronMD

Uniprot ID: O75335

Source protein: Liprin-alpha-4

Source gene: PPFIA4

Class: DEG_APCC_DBOX_1

Location: 676:684

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9939

ASA_SCORE: 101.2778

COIL: 0.7331

CONS_SCORE: 0.222

DSS_SCORE: 0.5942

HELIX: 0.2269

FCONS_SCORE: 1.0863

RIG_SCORE: 0.6857

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H687Y	TCGA-BH-A0AZ	BRCA	TCGA	RRKLLSPVS	DEG_APCC_DBOX_1	0.25
p.T667I	DO45205	LIRI	ICGC	RRKLLSPVS	DEG_APCC_DBOX_1	0.0833
p.R685L	DO26200	LUAD	ICGC	RRKLLSPVS	DEG_APCC_DBOX_1	0.3056
p.R685W	DO220886	MELA	ICGC	RRKLLSPVS	DEG_APCC_DBOX_1	0.3056
p.R689Q	DO37719	SKCM	ICGC	RRKLLSPVS	DEG_APCC_DBOX_1	0.1944
p.R689Q	H513	pleura	COSMIC	RRKLLSPVS	DEG_APCC_DBOX_1	0.1944
p.M666I	DO41752	UCEC	ICGC	RRKLLSPVS	DEG_APCC_DBOX_1	0.0556
p.P669L	DO41235	UCEC	ICGC	RRKLLSPVS	DEG_APCC_DBOX_1	0.1389
p.R690Q	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	RRKLLSPVS	DEG_APCC_DBOX_1	0.1667
p.R690Q	H513	pleura	COSMIC	RRKLLSPVS	DEG_APCC_DBOX_1	0.1667
p.L673I	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	RRKLLSPVS	DEG_APCC_DBOX_1	0.25
p.L673I	ACH-000875	Lung Cancer	CCLE	RRKLLSPVS	DEG_APCC_DBOX_1	0.25
p.L673I	NCI-H2347	lung	COSMIC	RRKLLSPVS	DEG_APCC_DBOX_1	0.25
p.H676R	SIDM01706	Hodgkin's Lymphoma	GDSC	RRKLLSPVS	DEG_APCC_DBOX_1	0.8244
p.H676R	ACH-001093	Non-Cancerous	CCLE	RRKLLSPVS	DEG_APCC_DBOX_1	0.8244
p.E688K	SIDM01640	Acute Myeloid Leukemia	GDSC	RRKLLSPVS	DEG_APCC_DBOX_1	0.2222
p.E688K	ACH-000602	Leukemia	CCLE	RRKLLSPVS	DEG_APCC_DBOX_1	0.2222
p.L672I	NCI-H2347	lung	COSMIC	RRKLLSPVS	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75335	Liprin-alpha-4	DEG_APCC_DBOX_1	676:684	RRKLLSPVS	APC,CDC20,FZR1	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons