DegronMD - O75362(ZNF217)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C999S	TCGA-25-2398	OV	TCGA	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1667
p.C999S	DO31250	OV	ICGC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1667
p.G1013E	TCGA-77-A5GB	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.2222
p.G1013E	DO45439	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.2222
p.R1015K	TCGA-AX-A1CE	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1667
p.R1015K	DO42280	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1667
p.N8H	TCGA-AX-A2HC	UCEC	TCGA	LLMYMD	LIG_APCC_ABBA_1	14:19	Mutation rewiring degron network	0.1667
p.N8H	DO41572	UCEC	ICGC	LLMYMD	LIG_APCC_ABBA_1	14:19	Mutation rewiring degron network	0.1667
p.S1007F	TCGA-DK-A1A7	BLCA	TCGA	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation altering degron motif	0.9093
p.S1007F	DO483	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation altering degron motif	0.9093
p.L28V	TCGA-FJ-A3ZF	BLCA	TCGA	LLMYMD	LIG_APCC_ABBA_1	14:19	Mutation rewiring degron network	0.0833
p.L28V	DO500	BLCA	ICGC	LLMYMD	LIG_APCC_ABBA_1	14:19	Mutation rewiring degron network	0.0833
p.S1018L	TCGA-RD-A8MW	STAD	TCGA	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.0833
p.S1018L	DO50134	STAD	ICGC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.0833
p.S27C	DO225136	BRCA	ICGC	LLMYMD	LIG_APCC_ABBA_1	14:19	Mutation rewiring degron network	0.1111
p.P1001S	DO233168	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.2222
p.I24V	DO45057	LINC	ICGC	LLMYMD	LIG_APCC_ABBA_1	14:19	Mutation rewiring degron network	0.1944
p.Y17F	SIDM01002	Breast Carcinoma	GDSC	LLMYMD	LIG_APCC_ABBA_1	14:19	Mutation altering degron motif	0.6417
p.Y17F	ACH-000117	Breast Cancer	CCLE	LLMYMD	LIG_APCC_ABBA_1	14:19	Mutation altering degron motif	0.6417
p.Y17F	EFM-192A	breast	COSMIC	LLMYMD	LIG_APCC_ABBA_1	14:19	Mutation altering degron motif	0.6417
p.K1014R	SIDM00087	Plasma Cell Myeloma	GDSC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation substituting flanking lysine	0.3056
p.P1016H	SIDM00654	Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1389
p.P1016H	ACH-000866	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1389
p.P1016H	NCI-H1048	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1389
p.C999G	SIDM01112	Osteosarcoma	GDSC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1667
p.C999G	SIDM00650	Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1667
p.C999G	SIDM00254	Neuroblastoma	GDSC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1667
p.C999G	SIDM01681	Non-Cancerous	GDSC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1667
p.C999G	SIDM00760	Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1667
p.V1017M	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1111
p.V1017M	ACH-000980	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1111
p.V1017M	NCI-H1155	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	1005:1009	Mutation rewiring degron network	0.1111
p.P10S	ACH-002027	Endometrial/Uterine Cancer	CCLE	LLMYMD	LIG_APCC_ABBA_1	14:19	Mutation rewiring degron network	0.2222

Kaplan plot for ZNF217 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF217

UniProt ID: O75362

Entrez ID: 7764

Protein name: Zinc finger protein 217

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF217 in