DegronMD

Uniprot ID: O75362

Source protein: Zinc finger protein 217

Source gene: ZNF217

Class: LIG_APCC_ABBA_1

Location: 14:19

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7752

ASA_SCORE: 90.45

COIL: 0.6132

CONS_SCORE: 0.6201

DSS_SCORE: 0.4324

HELIX: 0.1683

FCONS_SCORE: 1.1491

RIG_SCORE: 0.7869

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N8H	TCGA-AX-A2HC	UCEC	TCGA	LLMYMD	LIG_APCC_ABBA_1	0.1667
p.N8H	DO41572	UCEC	ICGC	LLMYMD	LIG_APCC_ABBA_1	0.1667
p.L28V	TCGA-FJ-A3ZF	BLCA	TCGA	LLMYMD	LIG_APCC_ABBA_1	0.0833
p.L28V	DO500	BLCA	ICGC	LLMYMD	LIG_APCC_ABBA_1	0.0833
p.S27C	DO225136	BRCA	ICGC	LLMYMD	LIG_APCC_ABBA_1	0.1111
p.I24V	DO45057	LINC	ICGC	LLMYMD	LIG_APCC_ABBA_1	0.1944
p.Y17F	SIDM01002	Breast Carcinoma	GDSC	LLMYMD	LIG_APCC_ABBA_1	0.6417
p.Y17F	ACH-000117	Breast Cancer	CCLE	LLMYMD	LIG_APCC_ABBA_1	0.6417
p.Y17F	EFM-192A	breast	COSMIC	LLMYMD	LIG_APCC_ABBA_1	0.6417
p.P10S	ACH-002027	Endometrial/Uterine Cancer	CCLE	LLMYMD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75362	Zinc finger protein 217	LIG_APCC_ABBA_1	14:19	LLMYMD	APC,CDC20,FZR1	0.7752	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons