DegronMD - O75381(PEX14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G18E	TCGA-14-2554	GBM	TCGA	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation altering degron motif	0.6087
p.G18E	DO11202	GBM	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation altering degron motif	0.6087
p.I29S	TCGA-2Z-A9J2	KIRP	TCGA	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.0833
p.I29S	DO219650	KIRP	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.0833
p.P17A	TCGA-76-4928	GBM	TCGA	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation altering degron motif	0.7503
p.A30V	TCGA-VQ-A8P2	STAD	TCGA	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.0556
p.A30V	DO51761	STAD	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.0556
p.E26K	TCGA-YC-A89H	BLCA	TCGA	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.1667
p.E26K	DO51948	BLCA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.1667
p.E26K	DO225300	BRCA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.1667
p.S14L	DO1160	BRCA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation altering degron motif	0.6556
p.S14L	DO219721	CESC	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation altering degron motif	0.6556
p.S14L	DO10132	COAD	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation altering degron motif	0.6556
p.E12D	DO1854	BRCA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.3056
p.V25I	DO7798	COAD	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.1944
p.S6L	DO222798	COCA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation blocking phosphorylation signal	0.5833
p.S6A	DO230659	LAML	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation blocking phosphorylation signal	0.5833
p.S6A	DO231140	LAML	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation blocking phosphorylation signal	0.5833
p.S6A	DO228941	LICA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation blocking phosphorylation signal	0.5833
p.Q26H	DO229022	LICA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.1667
p.D11Y	DO22893	LIHC	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.2778
p.S4P	DO220902	MELA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation blocking ubiquitination signal	0.5278
p.P27L	DO42568	UCEC	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.1389
p.H29Q	DO41235	UCEC	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.0833
p.R25G	SIDM00043	Head and Neck Carcinoma	GDSC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.1944
p.R25G	ACH-002297	Head and Neck Cancer	CCLE	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.1944
p.R25G	PCI-4B	upper aerodigestive tract	COSMIC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation rewiring degron network	0.1944
p.S14N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation altering degron motif	0.5958
p.S14N	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation altering degron motif	0.5958
p.S14N	ACH-000964	Leukemia	CCLE	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation altering degron motif	0.5958
p.S14N	ACH-001127	Leukemia	CCLE	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation altering degron motif	0.5958
p.S14N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PSSTPGSE	DEG_SCF_FBW7_2	13:20	Mutation altering degron motif	0.5958

Kaplan plot for PEX14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PEX14

UniProt ID: O75381

Entrez ID: 5195

Protein name: Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PEX14 in