DegronMD

Uniprot ID: O75381

Source protein: Peroxisomal membrane protein PEX14

Source gene: PEX14

Class: DEG_SCF_FBW7_2

Location: 13:20

E3 ligase: FBXW7

DEGRON score: 0.9566

ASA_SCORE: 87.8125

COIL: 0.9341

CONS_SCORE: 0.2843

DSS_SCORE: 0.7736

HELIX: 0.0465

FCONS_SCORE: 0.71

RIG_SCORE: 0.5143

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G18E	TCGA-14-2554	GBM	TCGA	PSSTPGSE	DEG_SCF_FBW7_2	0.6087
p.G18E	DO11202	GBM	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.6087
p.I29S	TCGA-2Z-A9J2	KIRP	TCGA	PSSTPGSE	DEG_SCF_FBW7_2	0.0833
p.I29S	DO219650	KIRP	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.0833
p.P17A	TCGA-76-4928	GBM	TCGA	PSSTPGSE	DEG_SCF_FBW7_2	0.7503
p.A30V	TCGA-VQ-A8P2	STAD	TCGA	PSSTPGSE	DEG_SCF_FBW7_2	0.0556
p.A30V	DO51761	STAD	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.0556
p.E26K	TCGA-YC-A89H	BLCA	TCGA	PSSTPGSE	DEG_SCF_FBW7_2	0.1667
p.E26K	DO51948	BLCA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.1667
p.E26K	DO225300	BRCA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.1667
p.S14L	DO1160	BRCA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.6556
p.S14L	DO219721	CESC	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.6556
p.S14L	DO10132	COAD	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.6556
p.E12D	DO1854	BRCA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.3056
p.V25I	DO7798	COAD	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.1944
p.S6L	DO222798	COCA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.5833
p.S6A	DO230659	LAML	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.5833
p.S6A	DO231140	LAML	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.5833
p.S6A	DO228941	LICA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.5833
p.Q26H	DO229022	LICA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.1667
p.D11Y	DO22893	LIHC	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.2778
p.S4P	DO220902	MELA	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.5278
p.P27L	DO42568	UCEC	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.1389
p.H29Q	DO41235	UCEC	ICGC	PSSTPGSE	DEG_SCF_FBW7_2	0.0833
p.R25G	SIDM00043	Head and Neck Carcinoma	GDSC	PSSTPGSE	DEG_SCF_FBW7_2	0.1944
p.R25G	ACH-002297	Head and Neck Cancer	CCLE	PSSTPGSE	DEG_SCF_FBW7_2	0.1944
p.R25G	PCI-4B	upper_aerodigestive_tract	COSMIC	PSSTPGSE	DEG_SCF_FBW7_2	0.1944
p.S14N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PSSTPGSE	DEG_SCF_FBW7_2	0.5958
p.S14N	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PSSTPGSE	DEG_SCF_FBW7_2	0.5958
p.S14N	ACH-000964	Leukemia	CCLE	PSSTPGSE	DEG_SCF_FBW7_2	0.5958
p.S14N	ACH-001127	Leukemia	CCLE	PSSTPGSE	DEG_SCF_FBW7_2	0.5958
p.S14N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPGSE	DEG_SCF_FBW7_2	0.5958

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTPGSE

Degron related mutations and impact score

Drug responses associated with PEX14 mutations

All proteins holding degron of PSSTPGSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75381	Peroxisomal membrane protein PEX14	DEG_SCF_FBW7_2	13:20	PSSTPGSE	FBXW7	0.9566	More...