DegronMD - O75425(MOSPD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P154S	TCGA-33-4583	LUSC	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.25
p.P154S	DO27112	LUSC	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.25
p.R153H	TCGA-63-A5MM	LUSC	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.2222
p.R153H	TCGA-A5-A2K5	UCEC	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.2222
p.R153H	TCGA-DU-6392	LGG	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.2222
p.R153H	DO22237	LGG	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.2222
p.R153H	DO219153	LUSC	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.2222
p.R153H	DO41379	UCEC	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.2222
p.P154T	TCGA-CJ-4904	KIRC	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.25
p.P154T	DO18213	KIRC	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.25
p.P148S	TCGA-CJ-5675	KIRC	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.0833
p.P148S	DO19833	KIRC	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.0833
p.R173S	TCGA-EE-A3AB	SKCM	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.0833
p.R173S	DO38057	SKCM	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.0833
p.P172L	TCGA-XK-AAIW	PRAD	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.1111
p.P172L	DO51407	PRAD	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.1111
p.R173H	DO233168	GACA	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.0833
p.R173H	DO233766	GACA	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.0833
p.R173C	DO35083	PACA	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.0833
p.A165T	DO232761	PBCA	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.3056
p.H171P	DO219881	SKCA	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.1389
p.H171P	H2810	pleura	COSMIC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.1389
p.R173L	SIDM00662	Melanoma	GDSC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.0833
p.R173L	SIDM00100	Mesothelioma	GDSC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.0833
p.R173L	SIDM01502	Endometrial Carcinoma	GDSC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.0833
p.R173L	SIDM01746	Osteosarcoma	GDSC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.0833
p.P157L	SIDM00284	Melanoma	GDSC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation altering degron motif	0.6471
p.P157L	ACH-000805	Skin Cancer	CCLE	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation altering degron motif	0.6471
p.P157L	COLO-679	skin	COSMIC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation altering degron motif	0.6471
p.P147L	COLO-679	skin	COSMIC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation rewiring degron network	0.0556
p.H161P	H2810	pleura	COSMIC	PAGTPPPT	DEG_SCF_FBW7_1	157:164	Mutation altering degron motif	0.7694

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MOSPD3

UniProt ID: O75425

Entrez ID: 64598

Protein name: Motile sperm domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MOSPD3 in