DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PAGTPPPT
Uniprot ID:
O75425
Source protein:
Motile sperm domain-containing protein 3
Source gene:
MOSPD3
Class:
DEG_SCF_FBW7_1
Location:
157:164
E3 ligase:
FBXW7
DEGRON score:
0.7969
ASA_SCORE:
79.3125
COIL:
0.9406
CONS_SCORE:
0.3138
DSS_SCORE:
0.8894
HELIX:
0.0321
FCONS_SCORE:
0.7852
RIG_SCORE:
0.486
Degron related mutations and impact score
Show
10
25
50
100
entries
Search:
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H161P
H2810
pleura
COSMIC
PAGTPPPT
DEG_SCF_FBW7_1
0.7694
p.P157L
SIDM00284
Melanoma
GDSC
PAGTPPPT
DEG_SCF_FBW7_1
0.6471
p.P157L
ACH-000805
Skin Cancer
CCLE
PAGTPPPT
DEG_SCF_FBW7_1
0.6471
p.P157L
COLO-679
skin
COSMIC
PAGTPPPT
DEG_SCF_FBW7_1
0.6471
p.A165T
DO232761
PBCA
ICGC
PAGTPPPT
DEG_SCF_FBW7_1
0.3056
p.P154S
TCGA-33-4583
LUSC
TCGA
PAGTPPPT
DEG_SCF_FBW7_1
0.25
p.P154S
DO27112
LUSC
ICGC
PAGTPPPT
DEG_SCF_FBW7_1
0.25
p.P154T
TCGA-CJ-4904
KIRC
TCGA
PAGTPPPT
DEG_SCF_FBW7_1
0.25
p.P154T
DO18213
KIRC
ICGC
PAGTPPPT
DEG_SCF_FBW7_1
0.25
p.R153H
TCGA-63-A5MM
LUSC
TCGA
PAGTPPPT
DEG_SCF_FBW7_1
0.2222
p.R153H
TCGA-A5-A2K5
UCEC
TCGA
PAGTPPPT
DEG_SCF_FBW7_1
0.2222
p.R153H
TCGA-DU-6392
LGG
TCGA
PAGTPPPT
DEG_SCF_FBW7_1
0.2222
p.R153H
DO22237
LGG
ICGC
PAGTPPPT
DEG_SCF_FBW7_1
0.2222
p.R153H
DO219153
LUSC
ICGC
PAGTPPPT
DEG_SCF_FBW7_1
0.2222
p.R153H
DO41379
UCEC
ICGC
PAGTPPPT
DEG_SCF_FBW7_1
0.2222
p.H171P
DO219881
SKCA
ICGC
PAGTPPPT
DEG_SCF_FBW7_1
0.1389
p.H171P
H2810
pleura
COSMIC
PAGTPPPT
DEG_SCF_FBW7_1
0.1389
p.P172L
TCGA-XK-AAIW
PRAD
TCGA
PAGTPPPT
DEG_SCF_FBW7_1
0.1111
p.P172L
DO51407
PRAD
ICGC
PAGTPPPT
DEG_SCF_FBW7_1
0.1111
p.P148S
TCGA-CJ-5675
KIRC
TCGA
PAGTPPPT
DEG_SCF_FBW7_1
0.0833
p.P148S
DO19833
KIRC
ICGC
PAGTPPPT
DEG_SCF_FBW7_1
0.0833
p.R173S
TCGA-EE-A3AB
SKCM
TCGA
PAGTPPPT
DEG_SCF_FBW7_1
0.0833
p.R173S
DO38057
SKCM
ICGC
PAGTPPPT
DEG_SCF_FBW7_1
0.0833
p.R173H
DO233168
GACA
ICGC
PAGTPPPT
DEG_SCF_FBW7_1
0.0833
p.R173H
DO233766
GACA
ICGC
PAGTPPPT
DEG_SCF_FBW7_1
0.0833
Showing 1 to 25 of 31 entries
Previous
1
2
Next
Drug responses associated with MOSPD3 mutations
Show
10
25
50
100
entries
Search:
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
Showing 0 to 0 of 0 entries
Previous
Next
All proteins holding degron of PAGTPPPT
Show
10
25
50
100
entries
Search:
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75425
Motile sperm domain-containing protein 3
DEG_SCF_FBW7_1
157:164
PAGTPPPT
FBXW7
0.7969
More...
Showing 1 to 1 of 1 entries
Previous
1
Next