DegronMD

Uniprot ID: O75425

Source protein: Motile sperm domain-containing protein 3

Source gene: MOSPD3

Class: DEG_SCF_FBW7_1

Location: 157:164

E3 ligase: FBXW7

DEGRON score: 0.7969

ASA_SCORE: 79.3125

COIL: 0.9406

CONS_SCORE: 0.3138

DSS_SCORE: 0.8894

HELIX: 0.0321

FCONS_SCORE: 0.7852

RIG_SCORE: 0.486

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P154S	TCGA-33-4583	LUSC	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	0.25
p.P154S	DO27112	LUSC	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	0.25
p.R153H	TCGA-63-A5MM	LUSC	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	0.2222
p.R153H	TCGA-A5-A2K5	UCEC	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	0.2222
p.R153H	TCGA-DU-6392	LGG	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	0.2222
p.R153H	DO22237	LGG	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	0.2222
p.R153H	DO219153	LUSC	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	0.2222
p.R153H	DO41379	UCEC	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	0.2222
p.P154T	TCGA-CJ-4904	KIRC	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	0.25
p.P154T	DO18213	KIRC	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	0.25
p.P148S	TCGA-CJ-5675	KIRC	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	0.0833
p.P148S	DO19833	KIRC	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	0.0833
p.R173S	TCGA-EE-A3AB	SKCM	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	0.0833
p.R173S	DO38057	SKCM	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	0.0833
p.P172L	TCGA-XK-AAIW	PRAD	TCGA	PAGTPPPT	DEG_SCF_FBW7_1	0.1111
p.P172L	DO51407	PRAD	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	0.1111
p.R173H	DO233168	GACA	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	0.0833
p.R173H	DO233766	GACA	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	0.0833
p.R173C	DO35083	PACA	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	0.0833
p.A165T	DO232761	PBCA	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	0.3056
p.H171P	DO219881	SKCA	ICGC	PAGTPPPT	DEG_SCF_FBW7_1	0.1389
p.H171P	H2810	pleura	COSMIC	PAGTPPPT	DEG_SCF_FBW7_1	0.1389
p.R173L	SIDM00662	Melanoma	GDSC	PAGTPPPT	DEG_SCF_FBW7_1	0.0833
p.R173L	SIDM00100	Mesothelioma	GDSC	PAGTPPPT	DEG_SCF_FBW7_1	0.0833
p.R173L	SIDM01502	Endometrial Carcinoma	GDSC	PAGTPPPT	DEG_SCF_FBW7_1	0.0833
p.R173L	SIDM01746	Osteosarcoma	GDSC	PAGTPPPT	DEG_SCF_FBW7_1	0.0833
p.P157L	SIDM00284	Melanoma	GDSC	PAGTPPPT	DEG_SCF_FBW7_1	0.6471
p.P157L	ACH-000805	Skin Cancer	CCLE	PAGTPPPT	DEG_SCF_FBW7_1	0.6471
p.P157L	COLO-679	skin	COSMIC	PAGTPPPT	DEG_SCF_FBW7_1	0.6471
p.P147L	COLO-679	skin	COSMIC	PAGTPPPT	DEG_SCF_FBW7_1	0.0556
p.H161P	H2810	pleura	COSMIC	PAGTPPPT	DEG_SCF_FBW7_1	0.7694

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PAGTPPPT

Degron related mutations and impact score

Drug responses associated with MOSPD3 mutations

All proteins holding degron of PAGTPPPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75425	Motile sperm domain-containing protein 3	DEG_SCF_FBW7_1	157:164	PAGTPPPT	FBXW7	0.7969	More...