DegronMD - O75439(PMPCB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D73N	TCGA-85-A5B5	LUSC	TCGA	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation altering degron motif	0.6932
p.D73N	TCGA-O2-A52W	LUSC	TCGA	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation altering degron motif	0.6932
p.D73N	DO50102	LUSC	ICGC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation altering degron motif	0.6932
p.D73N	DO219225	LUSC	ICGC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation altering degron motif	0.6932
p.G82V	TCGA-AB-2814	LAML	TCGA	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.2222
p.G82V	DO21869	LAML	ICGC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.2222
p.S71L	TCGA-EO-A22X	UCEC	TCGA	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.2778
p.S71L	TCGA-F5-6814	READ	TCGA	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.2778
p.S77L	TCGA-XF-A9ST	BLCA	TCGA	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation altering degron motif	0.6556
p.S77L	DO223599	BLCA	ICGC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation altering degron motif	0.6556
p.R68H	DO222762	COCA	ICGC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.1944
p.R68H	DO224778	LAML	ICGC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.1944
p.V88F	DO228952	LICA	ICGC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.0556
p.E67D	DO52205	LIHC	ICGC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.1667
p.N83T	DO50805	LIRI	ICGC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.1944
p.E76V	DO28190	OV	ICGC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation altering degron motif	0.7693
p.R70H	DO42753	UCEC	ICGC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.25
p.G75R	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation altering degron motif	0.7568
p.G75R	ACH-002301	Lymphoma	CCLE	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation altering degron motif	0.7568
p.G75R	RF-48	stomach	COSMIC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation altering degron motif	0.7568
p.C79F	SIDM00180	Kidney Carcinoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.3056
p.C79F	ACH-002155	Kidney Cancer	CCLE	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.3056
p.C79F	LB996-RCC	kidney	COSMIC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.3056
p.S71P	SIDM01045	Endometrial Carcinoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.2778
p.S71P	ACH-000978	Endometrial/Uterine Cancer	CCLE	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.2778
p.S71P	EN	endometrium	COSMIC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.2778
p.S65N	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.1111
p.S65N	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.1111
p.S65N	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.1111
p.S65N	ACH-000681	Lung Cancer	CCLE	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.1111
p.S65N	ACH-002337	Lung Cancer	CCLE	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.1111
p.S65N	A549	lung	COSMIC	DSGLST	DEG_SCF_TRCP1_1	73:78	Mutation rewiring degron network	0.1111

Kaplan plot for PMPCB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PMPCB

UniProt ID: O75439

Entrez ID: 9512

Protein name: Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (P-52)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PMPCB in