DegronMD

Uniprot ID: O75439

Source protein: Mitochondrial-processing peptidase subunit beta

Source gene: PMPCB

Class: DEG_SCF_TRCP1_1

Location: 73:78

E3 ligase: BTRC

DEGRON score: 0.9178

ASA_SCORE: 52.1833

COIL: 0.7883

CONS_SCORE: 0.4167

DSS_SCORE: 0.1911

HELIX: 0.0145

FCONS_SCORE: 0.6511

RIG_SCORE: 0.7547

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D73N	TCGA-85-A5B5	LUSC	TCGA	DSGLST	DEG_SCF_TRCP1_1	0.6932
p.D73N	TCGA-O2-A52W	LUSC	TCGA	DSGLST	DEG_SCF_TRCP1_1	0.6932
p.D73N	DO50102	LUSC	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.6932
p.D73N	DO219225	LUSC	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.6932
p.G82V	TCGA-AB-2814	LAML	TCGA	DSGLST	DEG_SCF_TRCP1_1	0.2222
p.G82V	DO21869	LAML	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.2222
p.S71L	TCGA-EO-A22X	UCEC	TCGA	DSGLST	DEG_SCF_TRCP1_1	0.2778
p.S71L	TCGA-F5-6814	READ	TCGA	DSGLST	DEG_SCF_TRCP1_1	0.2778
p.S77L	TCGA-XF-A9ST	BLCA	TCGA	DSGLST	DEG_SCF_TRCP1_1	0.6556
p.S77L	DO223599	BLCA	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.6556
p.R68H	DO222762	COCA	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.1944
p.R68H	DO224778	LAML	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.1944
p.V88F	DO228952	LICA	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.0556
p.E67D	DO52205	LIHC	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.1667
p.N83T	DO50805	LIRI	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.1944
p.E76V	DO28190	OV	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.7693
p.R70H	DO42753	UCEC	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.25
p.G75R	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	0.7568
p.G75R	ACH-002301	Lymphoma	CCLE	DSGLST	DEG_SCF_TRCP1_1	0.7568
p.G75R	RF-48	stomach	COSMIC	DSGLST	DEG_SCF_TRCP1_1	0.7568
p.C79F	SIDM00180	Kidney Carcinoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	0.3056
p.C79F	ACH-002155	Kidney Cancer	CCLE	DSGLST	DEG_SCF_TRCP1_1	0.3056
p.C79F	LB996-RCC	kidney	COSMIC	DSGLST	DEG_SCF_TRCP1_1	0.3056
p.S71P	SIDM01045	Endometrial Carcinoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	0.2778
p.S71P	ACH-000978	Endometrial/Uterine Cancer	CCLE	DSGLST	DEG_SCF_TRCP1_1	0.2778
p.S71P	EN	endometrium	COSMIC	DSGLST	DEG_SCF_TRCP1_1	0.2778
p.S65N	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	0.1111
p.S65N	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	0.1111
p.S65N	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	0.1111
p.S65N	ACH-000681	Lung Cancer	CCLE	DSGLST	DEG_SCF_TRCP1_1	0.1111
p.S65N	ACH-002337	Lung Cancer	CCLE	DSGLST	DEG_SCF_TRCP1_1	0.1111
p.S65N	A549	lung	COSMIC	DSGLST	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75439	Mitochondrial-processing peptidase subunit beta	DEG_SCF_TRCP1_1	73:78	DSGLST	BTRC	0.9178	More...
Q8IZ41	Ras and EF-hand domain-containing protein	DEG_SCF_TRCP1_1	437:442	DSGLST	BTRC	0.9838	More...
Q9BW04	Specifically androgen-regulated gene protein	DEG_SCF_TRCP1_1	66:71	DSGLST	BTRC	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGLST

Degron related mutations and impact score

Drug responses associated with PMPCB mutations

All proteins holding degron of DSGLST