DegronMD - Q8IZ41(RASEF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D450Y	TCGA-22-1002	LUSC	TCGA	DSGLST	DEG_SCF_TRCP1_1	437:442	Mutation rewiring degron network	0.1111
p.D450Y	DO26429	LUSC	ICGC	DSGLST	DEG_SCF_TRCP1_1	437:442	Mutation rewiring degron network	0.1111
p.G466R	TCGA-22-4613	LUSC	TCGA	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.1111
p.G466R	TCGA-XK-AAIW	PRAD	TCGA	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.1111
p.G466R	DO26468	LUSC	ICGC	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.1111
p.G466R	DO51407	PRAD	ICGC	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.1111
p.T488I	TCGA-AA-3833	COAD	TCGA	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.1944
p.T488I	DO9796	COAD	ICGC	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.1944
p.D437N	TCGA-AG-A002	READ	TCGA	DSGLST	DEG_SCF_TRCP1_1	437:442	Mutation altering degron motif	0.6932
p.G466W	TCGA-CK-4951	COAD	TCGA	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.1111
p.G466W	DO10582	COAD	ICGC	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.1111
p.S476L	TCGA-D3-A8GI	SKCM	TCGA	DASDTDVPDI	DEG_COP1_1	474:483	Mutation altering degron motif	0.7667
p.S476L	DO50284	SKCM	ICGC	DASDTDVPDI	DEG_COP1_1	474:483	Mutation altering degron motif	0.7667
p.D493Y	TCGA-DD-AACT	LIHC	TCGA	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.0556
p.D493Y	DO219563	LIHC	ICGC	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.0556
p.T488A	TCGA-DF-A2KU	UCEC	TCGA	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.1944
p.T488A	DO223286	UCEC	ICGC	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.1944
p.P481S	TCGA-DK-A6AW	BLCA	TCGA	DASDTDVPDI	DEG_COP1_1	474:483	Mutation altering degron motif	0.6752
p.P481S	DO48566	BLCA	ICGC	DASDTDVPDI	DEG_COP1_1	474:483	Mutation altering degron motif	0.6752
p.D429H	TCGA-EK-A2PG	CESC	TCGA	DSGLST	DEG_SCF_TRCP1_1	437:442	Mutation rewiring degron network	0.1111
p.D429H	DO49939	CESC	ICGC	DSGLST	DEG_SCF_TRCP1_1	437:442	Mutation rewiring degron network	0.1111
p.D474N	TCGA-MQ-A4LV	MESO	TCGA	DASDTDVPDI	DEG_COP1_1	474:483	Mutation altering degron motif	0.6932
p.V467L	DO234202	ESAD	ICGC	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.1389
p.H465Q	DO234202	ESAD	ICGC	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.0833
p.H465R	DO234177	ESAD	ICGC	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.0833
p.V428F	DO232224	PBCA	ICGC	DSGLST	DEG_SCF_TRCP1_1	437:442	Mutation rewiring degron network	0.0833
p.R484M	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.3056
p.R484M	ACH-000706	Lung Cancer	CCLE	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.3056
p.R484M	EKVX	lung	COSMIC	DASDTDVPDI	DEG_COP1_1	474:483	Mutation rewiring degron network	0.3056
p.C435Y	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	437:442	Mutation rewiring degron network	0.2778
p.C435Y	ACH-002220	Lymphoma	CCLE	DSGLST	DEG_SCF_TRCP1_1	437:442	Mutation rewiring degron network	0.2778
p.C435Y	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	DSGLST	DEG_SCF_TRCP1_1	437:442	Mutation rewiring degron network	0.2778

Kaplan plot for RASEF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RASEF

UniProt ID: Q8IZ41

Entrez ID: 158158

Protein name: Ras and EF-hand domain-containing protein (Ras-related protein Rab-45)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RASEF in