DegronMD

Uniprot ID: Q8IZ41

Source protein: Ras and EF-hand domain-containing protein

Source gene: RASEF

Class: DEG_COP1_1

Location: 474:483

E3 ligase: COP1

DEGRON score: 0.9974

ASA_SCORE: 72.25

COIL: 0.8249

CONS_SCORE: 0.419

DSS_SCORE: 0.6508

HELIX: 0.105

FCONS_SCORE: 1.0242

RIG_SCORE: 0.7099

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G466R	TCGA-22-4613	LUSC	TCGA	DASDTDVPDI	DEG_COP1_1	0.1111
p.G466R	TCGA-XK-AAIW	PRAD	TCGA	DASDTDVPDI	DEG_COP1_1	0.1111
p.G466R	DO26468	LUSC	ICGC	DASDTDVPDI	DEG_COP1_1	0.1111
p.G466R	DO51407	PRAD	ICGC	DASDTDVPDI	DEG_COP1_1	0.1111
p.T488I	TCGA-AA-3833	COAD	TCGA	DASDTDVPDI	DEG_COP1_1	0.1944
p.T488I	DO9796	COAD	ICGC	DASDTDVPDI	DEG_COP1_1	0.1944
p.G466W	TCGA-CK-4951	COAD	TCGA	DASDTDVPDI	DEG_COP1_1	0.1111
p.G466W	DO10582	COAD	ICGC	DASDTDVPDI	DEG_COP1_1	0.1111
p.S476L	TCGA-D3-A8GI	SKCM	TCGA	DASDTDVPDI	DEG_COP1_1	0.7667
p.S476L	DO50284	SKCM	ICGC	DASDTDVPDI	DEG_COP1_1	0.7667
p.D493Y	TCGA-DD-AACT	LIHC	TCGA	DASDTDVPDI	DEG_COP1_1	0.0556
p.D493Y	DO219563	LIHC	ICGC	DASDTDVPDI	DEG_COP1_1	0.0556
p.T488A	TCGA-DF-A2KU	UCEC	TCGA	DASDTDVPDI	DEG_COP1_1	0.1944
p.T488A	DO223286	UCEC	ICGC	DASDTDVPDI	DEG_COP1_1	0.1944
p.P481S	TCGA-DK-A6AW	BLCA	TCGA	DASDTDVPDI	DEG_COP1_1	0.6752
p.P481S	DO48566	BLCA	ICGC	DASDTDVPDI	DEG_COP1_1	0.6752
p.D474N	TCGA-MQ-A4LV	MESO	TCGA	DASDTDVPDI	DEG_COP1_1	0.6932
p.V467L	DO234202	ESAD	ICGC	DASDTDVPDI	DEG_COP1_1	0.1389
p.H465Q	DO234202	ESAD	ICGC	DASDTDVPDI	DEG_COP1_1	0.0833
p.H465R	DO234177	ESAD	ICGC	DASDTDVPDI	DEG_COP1_1	0.0833
p.R484M	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	DASDTDVPDI	DEG_COP1_1	0.3056
p.R484M	ACH-000706	Lung Cancer	CCLE	DASDTDVPDI	DEG_COP1_1	0.3056
p.R484M	EKVX	lung	COSMIC	DASDTDVPDI	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZ41	Ras and EF-hand domain-containing protein	DEG_COP1_1	474:483	DASDTDVPDI	COP1	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons