DegronMD

Uniprot ID: Q8IZ41

Source protein: Ras and EF-hand domain-containing protein

Source gene: RASEF

Class: DEG_SCF_TRCP1_1

Location: 437:442

E3 ligase: BTRC

DEGRON score: 0.9838

ASA_SCORE: 65.8

COIL: 0.8297

CONS_SCORE: 0.6808

DSS_SCORE: 0.4373

HELIX: 0.1085

FCONS_SCORE: 1.3589

RIG_SCORE: 0.7031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D450Y	TCGA-22-1002	LUSC	TCGA	DSGLST	DEG_SCF_TRCP1_1	0.1111
p.D450Y	DO26429	LUSC	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.1111
p.D437N	TCGA-AG-A002	READ	TCGA	DSGLST	DEG_SCF_TRCP1_1	0.6932
p.D429H	TCGA-EK-A2PG	CESC	TCGA	DSGLST	DEG_SCF_TRCP1_1	0.1111
p.D429H	DO49939	CESC	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.1111
p.V428F	DO232224	PBCA	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.0833
p.C435Y	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	0.2778
p.C435Y	ACH-002220	Lymphoma	CCLE	DSGLST	DEG_SCF_TRCP1_1	0.2778
p.C435Y	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLST	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75439	Mitochondrial-processing peptidase subunit beta	DEG_SCF_TRCP1_1	73:78	DSGLST	BTRC	0.9178	More...
Q8IZ41	Ras and EF-hand domain-containing protein	DEG_SCF_TRCP1_1	437:442	DSGLST	BTRC	0.9838	More...
Q9BW04	Specifically androgen-regulated gene protein	DEG_SCF_TRCP1_1	66:71	DSGLST	BTRC	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons