DegronMD

Uniprot ID: Q9BW04

Source protein: Specifically androgen-regulated gene protein

Source gene: SARG

Class: DEG_SCF_TRCP1_1

Location: 66:71

E3 ligase: BTRC

DEGRON score: 0.9976

ASA_SCORE: 53.1

COIL: 0.8707

CONS_SCORE: 0.9172

DSS_SCORE: 0.7156

HELIX: 0.0813

FCONS_SCORE: 1.3099

RIG_SCORE: 0.6385

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T57I	TCGA-AX-A0J1	UCEC	TCGA	DSGLST	DEG_SCF_TRCP1_1	0.0833
p.T57I	DO41199	UCEC	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.0833
p.E64D	TCGA-BR-8059	STAD	TCGA	DSGLST	DEG_SCF_TRCP1_1	0.2778
p.E64D	DO38443	STAD	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.2778
p.D66N	TCGA-DD-A3A9	LIHC	TCGA	DSGLST	DEG_SCF_TRCP1_1	0.6932
p.D66N	TCGA-FJ-A3Z9	BLCA	TCGA	DSGLST	DEG_SCF_TRCP1_1	0.6932
p.D66N	DO44065	BLCA	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.6932
p.D66N	DO44888	LIHC	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.6932
p.E56D	DO52597	BOCA	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.0556
p.T63K	DO229025	LICA	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.6944
p.S67R	DO229027	LICA	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.7427
p.S67R	DO230998	LUSC	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.7427
p.S67R	DO224576	LUSC	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.7427
p.T63M	DO48701	LIRI	ICGC	DSGLST	DEG_SCF_TRCP1_1	0.6944
p.T57N	SIDM00484	Thyroid Gland Carcinoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	0.0833
p.T57N	ACH-001321	Thyroid Cancer	CCLE	DSGLST	DEG_SCF_TRCP1_1	0.0833
p.S70F	SIDM00604	Oral Cavity Carcinoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	0.6871
p.H69Y	ACH-000762	Head and Neck Cancer	CCLE	DSGLST	DEG_SCF_TRCP1_1	0.7229
p.P56S	ACH-000939	Sarcoma	CCLE	DSGLST	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75439	Mitochondrial-processing peptidase subunit beta	DEG_SCF_TRCP1_1	73:78	DSGLST	BTRC	0.9178	More...
Q8IZ41	Ras and EF-hand domain-containing protein	DEG_SCF_TRCP1_1	437:442	DSGLST	BTRC	0.9838	More...
Q9BW04	Specifically androgen-regulated gene protein	DEG_SCF_TRCP1_1	66:71	DSGLST	BTRC	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons