DegronMD - Q9BW04(SARG)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K511N	TCGA-05-4396	LUAD	TCGA	PKTST	DEG_SPOP_SBC_1	503:507	Mutation substituting flanking lysine	0.3333
p.K511N	DO23838	LUAD	ICGC	PKTST	DEG_SPOP_SBC_1	503:507	Mutation substituting flanking lysine	0.3333
p.G512S	TCGA-06-2563	GBM	TCGA	PKTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1944
p.G512S	DO11525	GBM	ICGC	PKTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1944
p.E240Q	TCGA-39-5022	LUSC	TCGA	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.2222
p.E240Q	DO27604	LUSC	ICGC	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.2222
p.S234C	TCGA-50-5946	LUAD	TCGA	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.643
p.S234C	DO24556	LUAD	ICGC	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.643
p.S236P	TCGA-59-2352	OV	TCGA	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.6752
p.S236P	DO28068	OV	ICGC	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.6752
p.L593P	TCGA-91-6831	LUAD	TCGA	RREALKKLG	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.7582
p.L593P	DO23753	LUAD	ICGC	RREALKKLG	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.7582
p.E327K	TCGA-98-8021	LUSC	TCGA	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.1944
p.E327K	DO27468	LUSC	ICGC	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.1944
p.R324C	TCGA-AP-A1E4	UCEC	TCGA	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.1111
p.R324C	DO42777	UCEC	ICGC	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.1111
p.A501V	TCGA-AX-A0J1	UCEC	TCGA	PKTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2778
p.A501V	DO41199	UCEC	ICGC	PKTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2778
p.T57I	TCGA-AX-A0J1	UCEC	TCGA	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation rewiring degron network	0.0833
p.T57I	DO41199	UCEC	ICGC	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation rewiring degron network	0.0833
p.G331E	TCGA-AZ-6599	COAD	TCGA	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.3056
p.G331E	DO10606	COAD	ICGC	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.3056
p.R324H	TCGA-B5-A0JY	UCEC	TCGA	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.1111
p.R324H	DO43041	UCEC	ICGC	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.1111
p.L596P	TCGA-B5-A3FA	UCEC	TCGA	RREALKKLG	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.7582
p.L596P	DO52402	UCEC	ICGC	RREALKKLG	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.7582
p.E64D	TCGA-BR-8059	STAD	TCGA	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation rewiring degron network	0.2778
p.E64D	DO38443	STAD	ICGC	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation rewiring degron network	0.2778
p.R324S	TCGA-D3-A2JP	SKCM	TCGA	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.1111
p.R324S	DO47407	SKCM	ICGC	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.1111
p.D66N	TCGA-DD-A3A9	LIHC	TCGA	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation altering degron motif	0.6932
p.D66N	TCGA-FJ-A3Z9	BLCA	TCGA	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation altering degron motif	0.6932
p.D66N	DO44065	BLCA	ICGC	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation altering degron motif	0.6932
p.D66N	DO44888	LIHC	ICGC	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation altering degron motif	0.6932
p.P330L	TCGA-EE-A2MR	SKCM	TCGA	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.2778
p.P330L	DO37819	SKCM	ICGC	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.2778
p.S235N	TCGA-EO-A3AV	UCEC	TCGA	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.5958
p.S235N	DO52412	UCEC	ICGC	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.5958
p.S235N	SIDM00879	Breast Carcinoma	GDSC	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.5958
p.S235N	SIDM00954	Breast Carcinoma	GDSC	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.5958
p.S235N	SIDM00257	Neuroblastoma	GDSC	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.5958
p.R589I	TCGA-EY-A1G8	UCEC	TCGA	RREALKKLG	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.6991
p.R589I	DO43578	UCEC	ICGC	RREALKKLG	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.6991
p.A346S	TCGA-FI-A2D5	UCEC	TCGA	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.0833
p.A346S	DO41331	UCEC	ICGC	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.0833
p.S244L	TCGA-IR-A3LK	CESC	TCGA	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.1111
p.S244L	DO44299	CESC	ICGC	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.1111
p.H231Y	TCGA-WE-AAA0	SKCM	TCGA	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.6118
p.H231Y	DO51294	SKCM	ICGC	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.6118
p.R347H	TCGA-ZS-A9CE	LIHC	TCGA	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.0556
p.R347H	DO49720	LIHC	ICGC	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.0556
p.S323P	DO48461	BLCA	ICGC	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.0833
p.E56D	DO52597	BOCA	ICGC	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation rewiring degron network	0.0556
p.S508Y	DO8730	COAD	ICGC	PKTST	DEG_SPOP_SBC_1	503:507	Mutation blocking phosphorylation signal	0.75
p.G597V	DO223074	ESCA	ICGC	RREALKKLG	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.6421
p.G220E	DO228750	GACA	ICGC	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.0556
p.S502G	DO233260	GACA	ICGC	PKTST	DEG_SPOP_SBC_1	503:507	Mutation blocking phosphorylation signal	0.75
p.G220V	DO233732	GACA	ICGC	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.0556
p.Q341K	DO229019	LICA	ICGC	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.2222
p.T63K	DO229025	LICA	ICGC	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation blocking phosphorylation signal	0.6944
p.S67R	DO229027	LICA	ICGC	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation altering degron motif	0.7427
p.S67R	DO230998	LUSC	ICGC	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation altering degron motif	0.7427
p.S67R	DO224576	LUSC	ICGC	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation altering degron motif	0.7427
p.P233Q	DO229035	LICA	ICGC	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.7035
p.T63M	DO48701	LIRI	ICGC	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation blocking phosphorylation signal	0.6944
p.E238K	DO222868	MELA	ICGC	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.2778
p.E238K	SIDM00190	Melanoma	GDSC	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.2778
p.E238K	ACH-002097	Skin Cancer	CCLE	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.2778
p.E591K	DO222880	MELA	ICGC	RREALKKLG	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.591
p.T57N	SIDM00484	Thyroid Gland Carcinoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation rewiring degron network	0.0833
p.T57N	ACH-001321	Thyroid Cancer	CCLE	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation rewiring degron network	0.0833
p.D500A	SIDM01265	Plasma Cell Myeloma	GDSC	PKTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.D500A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.D500A	SIDM00807	Bladder Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.S493G	SIDM00491	Thyroid Gland Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.T497A	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	503:507	Mutation blocking phosphorylation signal	0.6111
p.G512D	SIDM00679	Cervical Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1944
p.S70F	SIDM00604	Oral Cavity Carcinoma	GDSC	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation altering degron motif	0.6871
p.S330N	ACH-000516	Bone Cancer	CCLE	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.2778
p.S330N	ACH-000650	Skin Cancer	CCLE	DSGLIS	DEG_SCF_TRCP1_1	332:337	Mutation rewiring degron network	0.2778
p.H69Y	ACH-000762	Head and Neck Cancer	CCLE	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation altering degron motif	0.7229
p.P56S	ACH-000939	Sarcoma	CCLE	DSGLST	DEG_SCF_TRCP1_1	66:71	Mutation rewiring degron network	0.0556
p.T225A	ACH-000978	Endometrial/Uterine Cancer	CCLE	LHTPSSS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SARG

UniProt ID: Q9BW04

Entrez ID: 79098

Protein name: Specifically androgen-regulated gene protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SARG in