DegronMD

Uniprot ID: Q9BW04

Source protein: Specifically androgen-regulated gene protein

Source gene: SARG

Class: DEG_SCF_TRCP1_1

Location: 332:337

E3 ligase: BTRC

DEGRON score: 0.9597

ASA_SCORE: 79.75

COIL: 0.7983

CONS_SCORE: 0.4655

DSS_SCORE: 0.5543

HELIX: 0.1715

FCONS_SCORE: 0.8377

RIG_SCORE: 0.6629

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E327K	TCGA-98-8021	LUSC	TCGA	DSGLIS	DEG_SCF_TRCP1_1	0.1944
p.E327K	DO27468	LUSC	ICGC	DSGLIS	DEG_SCF_TRCP1_1	0.1944
p.R324C	TCGA-AP-A1E4	UCEC	TCGA	DSGLIS	DEG_SCF_TRCP1_1	0.1111
p.R324C	DO42777	UCEC	ICGC	DSGLIS	DEG_SCF_TRCP1_1	0.1111
p.G331E	TCGA-AZ-6599	COAD	TCGA	DSGLIS	DEG_SCF_TRCP1_1	0.3056
p.G331E	DO10606	COAD	ICGC	DSGLIS	DEG_SCF_TRCP1_1	0.3056
p.R324H	TCGA-B5-A0JY	UCEC	TCGA	DSGLIS	DEG_SCF_TRCP1_1	0.1111
p.R324H	DO43041	UCEC	ICGC	DSGLIS	DEG_SCF_TRCP1_1	0.1111
p.R324S	TCGA-D3-A2JP	SKCM	TCGA	DSGLIS	DEG_SCF_TRCP1_1	0.1111
p.R324S	DO47407	SKCM	ICGC	DSGLIS	DEG_SCF_TRCP1_1	0.1111
p.P330L	TCGA-EE-A2MR	SKCM	TCGA	DSGLIS	DEG_SCF_TRCP1_1	0.2778
p.P330L	DO37819	SKCM	ICGC	DSGLIS	DEG_SCF_TRCP1_1	0.2778
p.A346S	TCGA-FI-A2D5	UCEC	TCGA	DSGLIS	DEG_SCF_TRCP1_1	0.0833
p.A346S	DO41331	UCEC	ICGC	DSGLIS	DEG_SCF_TRCP1_1	0.0833
p.R347H	TCGA-ZS-A9CE	LIHC	TCGA	DSGLIS	DEG_SCF_TRCP1_1	0.0556
p.R347H	DO49720	LIHC	ICGC	DSGLIS	DEG_SCF_TRCP1_1	0.0556
p.S323P	DO48461	BLCA	ICGC	DSGLIS	DEG_SCF_TRCP1_1	0.0833
p.Q341K	DO229019	LICA	ICGC	DSGLIS	DEG_SCF_TRCP1_1	0.2222
p.S330N	ACH-000516	Bone Cancer	CCLE	DSGLIS	DEG_SCF_TRCP1_1	0.2778
p.S330N	ACH-000650	Skin Cancer	CCLE	DSGLIS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BW04	Specifically androgen-regulated gene protein	DEG_SCF_TRCP1_1	332:337	DSGLIS	BTRC	0.9597	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons