DegronMD

Uniprot ID: Q9BW04

Source protein: Specifically androgen-regulated gene protein

Source gene: SARG

Class: DEG_SPOP_SBC_1

Location: 503:507

E3 ligase: SPOP

DEGRON score: 0.5589

ASA_SCORE: 92.66

COIL: 0.843

CONS_SCORE: 0.4407

DSS_SCORE: 0.5259

HELIX: 0.0866

FCONS_SCORE: 0.9364

RIG_SCORE: 0.6515

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K511N	TCGA-05-4396	LUAD	TCGA	PKTST	DEG_SPOP_SBC_1	0.3333
p.K511N	DO23838	LUAD	ICGC	PKTST	DEG_SPOP_SBC_1	0.3333
p.G512S	TCGA-06-2563	GBM	TCGA	PKTST	DEG_SPOP_SBC_1	0.1944
p.G512S	DO11525	GBM	ICGC	PKTST	DEG_SPOP_SBC_1	0.1944
p.A501V	TCGA-AX-A0J1	UCEC	TCGA	PKTST	DEG_SPOP_SBC_1	0.2778
p.A501V	DO41199	UCEC	ICGC	PKTST	DEG_SPOP_SBC_1	0.2778
p.S508Y	DO8730	COAD	ICGC	PKTST	DEG_SPOP_SBC_1	0.75
p.S502G	DO233260	GACA	ICGC	PKTST	DEG_SPOP_SBC_1	0.75
p.D500A	SIDM01265	Plasma Cell Myeloma	GDSC	PKTST	DEG_SPOP_SBC_1	0.25
p.D500A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	0.25
p.D500A	SIDM00807	Bladder Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	0.25
p.S493G	SIDM00491	Thyroid Gland Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	0.0556
p.T497A	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	0.6111
p.G512D	SIDM00679	Cervical Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70Z35	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein	DEG_SPOP_SBC_1	948:952	PKTST	SPOP	0.9793	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	41:45	PKTST	SPOP	0.9606	More...
Q96NE9	FERM domain-containing protein 6	DEG_SPOP_SBC_1	534:538	PKTST	SPOP	0.7639	More...
Q9BW04	Specifically androgen-regulated gene protein	DEG_SPOP_SBC_1	503:507	PKTST	SPOP	0.5589	More...
Q8IYT1	Golgi associated RAB2 interactor protein 4	DEG_SPOP_SBC_1	260:264	PKTST	SPOP	0.961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons