DegronMD

Uniprot ID: Q96NE9

Source protein: FERM domain-containing protein 6

Source gene: FRMD6

Class: DEG_SPOP_SBC_1

Location: 534:538

E3 ligase: SPOP

DEGRON score: 0.7639

ASA_SCORE: 101.34

COIL: 0.9336

CONS_SCORE: 0.6279

DSS_SCORE: 0.4945

HELIX: 0.048

FCONS_SCORE: 0.9721

RIG_SCORE: 0.6902

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D546G	TCGA-13-1481	OV	TCGA	PKTST	DEG_SPOP_SBC_1	0.1111
p.T538A	TCGA-86-8073	LUAD	TCGA	PKTST	DEG_SPOP_SBC_1	0.7139
p.L526V	TCGA-AO-A03M	BRCA	TCGA	PKTST	DEG_SPOP_SBC_1	0.1111
p.P534R	TCGA-CV-6937	HNSC	TCGA	PKTST	DEG_SPOP_SBC_1	0.7512
p.S544I	TCGA-DU-6392	LGG	TCGA	PKTST	DEG_SPOP_SBC_1	0.6111
p.R532Q	TCGA-EA-A410	CESC	TCGA	PKTST	DEG_SPOP_SBC_1	0.2778
p.R532L	TCGA-EE-A181	SKCM	TCGA	PKTST	DEG_SPOP_SBC_1	0.2778
p.S537F	TCGA-FS-A4FD	SKCM	TCGA	PKTST	DEG_SPOP_SBC_1	0.7982
p.D547Y	TCGA-L5-A43C	ESCA	TCGA	PKTST	DEG_SPOP_SBC_1	0.0833
p.R524Q	DO49929	CESC	ICGC	PKTST	DEG_SPOP_SBC_1	0.0556
p.R524W	DO233693	GACA	ICGC	PKTST	DEG_SPOP_SBC_1	0.0556
p.P526R	DO14155	HNSC	ICGC	PKTST	DEG_SPOP_SBC_1	0.1111
p.S536I	DO22237	LGG	ICGC	PKTST	DEG_SPOP_SBC_1	0.7341
p.T530A	DO23624	LUAD	ICGC	PKTST	DEG_SPOP_SBC_1	0.2222
p.D538G	DO31789	OV	ICGC	PKTST	DEG_SPOP_SBC_1	0.7198
p.S529F	DO37699	SKCM	ICGC	PKTST	DEG_SPOP_SBC_1	0.6389
p.R524L	DO37444	SKCM	ICGC	PKTST	DEG_SPOP_SBC_1	0.0556
p.R541K	DO38404	STAD	ICGC	PKTST	DEG_SPOP_SBC_1	0.25
p.R541K	DO42023	UCEC	ICGC	PKTST	DEG_SPOP_SBC_1	0.25
p.L548M	DO41752	UCEC	ICGC	PKTST	DEG_SPOP_SBC_1	0.0556
p.D539N	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKTST	DEG_SPOP_SBC_1	0.3056
p.D539N	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	PKTST	DEG_SPOP_SBC_1	0.3056
p.R541I	ACH-000866	Lung Cancer	CCLE	PKTST	DEG_SPOP_SBC_1	0.25
p.R541I	NCI-H1048	lung	COSMIC	PKTST	DEG_SPOP_SBC_1	0.25
p.D531N	ACH-002220	Lymphoma	CCLE	PKTST	DEG_SPOP_SBC_1	0.25
p.D531N	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	PKTST	DEG_SPOP_SBC_1	0.25
p.F547S	KO52	haematopoietic_and_lymphoid_tissue	COSMIC	PKTST	DEG_SPOP_SBC_1	0.0833
p.F547S	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	PKTST	DEG_SPOP_SBC_1	0.0833
p.V544A	HCC-15	lung	COSMIC	PKTST	DEG_SPOP_SBC_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70Z35	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein	DEG_SPOP_SBC_1	948:952	PKTST	SPOP	0.9793	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	41:45	PKTST	SPOP	0.9606	More...
Q96NE9	FERM domain-containing protein 6	DEG_SPOP_SBC_1	534:538	PKTST	SPOP	0.7639	More...
Q9BW04	Specifically androgen-regulated gene protein	DEG_SPOP_SBC_1	503:507	PKTST	SPOP	0.5589	More...
Q8IYT1	Golgi associated RAB2 interactor protein 4	DEG_SPOP_SBC_1	260:264	PKTST	SPOP	0.961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKTST

Degron related mutations and impact score

Drug responses associated with FRMD6 mutations

All proteins holding degron of PKTST