DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 41:45

E3 ligase: SPOP

DEGRON score: 0.9606

ASA_SCORE: 104.44

COIL: 0.842

CONS_SCORE: 0

DSS_SCORE: 0.501

HELIX: 0.022

FCONS_SCORE: 0

RIG_SCORE: 0.6815

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I48M	TCGA-34-8454	LUSC	TCGA	PKTST	DEG_SPOP_SBC_1	0.25
p.I48M	DO50094	LUSC	ICGC	PKTST	DEG_SPOP_SBC_1	0.25
p.S44C	TCGA-AJ-A3QS	UCEC	TCGA	PKTST	DEG_SPOP_SBC_1	0.7541
p.S44C	DO41349	UCEC	ICGC	PKTST	DEG_SPOP_SBC_1	0.7541
p.T38N	TCGA-BR-8384	STAD	TCGA	PKTST	DEG_SPOP_SBC_1	0.25
p.T38N	DO47749	STAD	ICGC	PKTST	DEG_SPOP_SBC_1	0.25
p.G36R	TCGA-DA-A960	SKCM	TCGA	PKTST	DEG_SPOP_SBC_1	0.1944
p.G36R	DO219482	SKCM	ICGC	PKTST	DEG_SPOP_SBC_1	0.1944
p.A47S	TCGA-DK-AA6U	BLCA	TCGA	PKTST	DEG_SPOP_SBC_1	0.2778
p.A47S	DO219008	BLCA	ICGC	PKTST	DEG_SPOP_SBC_1	0.2778
p.E52K	TCGA-GF-A6C9	SKCM	TCGA	PKTST	DEG_SPOP_SBC_1	0.1389
p.E52K	DO51254	SKCM	ICGC	PKTST	DEG_SPOP_SBC_1	0.1389
p.G36E	DO222868	MELA	ICGC	PKTST	DEG_SPOP_SBC_1	0.1944
p.P41L	DO230583	PRAD	ICGC	PKTST	DEG_SPOP_SBC_1	0.7582
p.D31N	DO229462	SKCA	ICGC	PKTST	DEG_SPOP_SBC_1	0.0556
p.G46D	SIDM00254	Neuroblastoma	GDSC	PKTST	DEG_SPOP_SBC_1	0.3056
p.G46D	SIDM00720	Mesothelioma	GDSC	PKTST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70Z35	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein	DEG_SPOP_SBC_1	948:952	PKTST	SPOP	0.9793	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	41:45	PKTST	SPOP	0.9606	More...
Q96NE9	FERM domain-containing protein 6	DEG_SPOP_SBC_1	534:538	PKTST	SPOP	0.7639	More...
Q9BW04	Specifically androgen-regulated gene protein	DEG_SPOP_SBC_1	503:507	PKTST	SPOP	0.5589	More...
Q8IYT1	Golgi associated RAB2 interactor protein 4	DEG_SPOP_SBC_1	260:264	PKTST	SPOP	0.961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons