DegronMD - Q96NE9(FRMD6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D546G	TCGA-13-1481	OV	TCGA	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.1111
p.T538A	TCGA-86-8073	LUAD	TCGA	PKTST	DEG_SPOP_SBC_1	534:538	Mutation altering degron motif	0.7139
p.L526V	TCGA-AO-A03M	BRCA	TCGA	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.1111
p.P534R	TCGA-CV-6937	HNSC	TCGA	PKTST	DEG_SPOP_SBC_1	534:538	Mutation altering degron motif	0.7512
p.S544I	TCGA-DU-6392	LGG	TCGA	PKTST	DEG_SPOP_SBC_1	534:538	Mutation blocking phosphorylation signal	0.6111
p.R532Q	TCGA-EA-A410	CESC	TCGA	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.2778
p.R532L	TCGA-EE-A181	SKCM	TCGA	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.2778
p.S537F	TCGA-FS-A4FD	SKCM	TCGA	PKTST	DEG_SPOP_SBC_1	534:538	Mutation altering degron motif	0.7982
p.D547Y	TCGA-L5-A43C	ESCA	TCGA	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.0833
p.R524Q	DO49929	CESC	ICGC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.0556
p.R524W	DO233693	GACA	ICGC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.0556
p.P526R	DO14155	HNSC	ICGC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.1111
p.S536I	DO22237	LGG	ICGC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation altering degron motif	0.7341
p.T530A	DO23624	LUAD	ICGC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.2222
p.D538G	DO31789	OV	ICGC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation altering degron motif	0.7198
p.S529F	DO37699	SKCM	ICGC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation blocking phosphorylation signal	0.6389
p.R524L	DO37444	SKCM	ICGC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.0556
p.R541K	DO38404	STAD	ICGC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.25
p.R541K	DO42023	UCEC	ICGC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.25
p.L548M	DO41752	UCEC	ICGC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.0556
p.D539N	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.3056
p.D539N	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.3056
p.R541I	ACH-000866	Lung Cancer	CCLE	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.25
p.R541I	NCI-H1048	lung	COSMIC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.25
p.D531N	ACH-002220	Lymphoma	CCLE	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.25
p.D531N	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.25
p.F547S	KO52	haematopoietic and lymphoid tissue	COSMIC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.0833
p.F547S	LC4-1	haematopoietic and lymphoid tissue	COSMIC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.0833
p.V544A	HCC-15	lung	COSMIC	PKTST	DEG_SPOP_SBC_1	534:538	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for FRMD6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRMD6

UniProt ID: Q96NE9

Entrez ID: 122786

Protein name: FERM domain-containing protein 6 (Willin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FRMD6 in