DegronMD - Q8IYT1(GARIN4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P270T	TCGA-55-8089	LUAD	TCGA	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1667
p.P270T	DO23690	LUAD	ICGC	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1667
p.A257V	TCGA-67-3771	LUAD	TCGA	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.25
p.A257V	DO25797	LUAD	ICGC	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.25
p.P188Q	TCGA-BT-A20N	BLCA	TCGA	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1389
p.P188Q	DO550	BLCA	ICGC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1389
p.T272I	TCGA-D1-A103	UCEC	TCGA	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1111
p.T272I	DO42312	UCEC	ICGC	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1111
p.N256S	TCGA-DD-AACP	LIHC	TCGA	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.2222
p.N256S	DO52210	LIHC	ICGC	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.2222
p.G206R	TCGA-EE-A20C	SKCM	TCGA	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1667
p.G206R	DO222775	MELA	ICGC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1667
p.G206R	DO47665	SKCM	ICGC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1667
p.P260S	TCGA-F5-6814	READ	TCGA	PKTST	DEG_SPOP_SBC_1	260:264	Mutation altering degron motif	0.6752
p.P260S	DO36556	READ	ICGC	PKTST	DEG_SPOP_SBC_1	260:264	Mutation altering degron motif	0.6752
p.S258F	TCGA-FW-A3R5	SKCM	TCGA	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.2778
p.S258F	DO37406	SKCM	ICGC	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.2778
p.M195I	TCGA-LN-A49V	ESCA	TCGA	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6507
p.P188T	TCGA-NJ-A55R	LUAD	TCGA	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1389
p.P188T	DO218947	LUAD	ICGC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1389
p.N253S	DO229010	COCA	ICGC	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1389
p.S204R	SIDM01137	Pancreatic Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2222
p.S204R	ACH-000235	Pancreatic Cancer	CCLE	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2222
p.S204R	PANC-04-03	pancreas	COSMIC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2222
p.A271G	SIDM00935	Other Solid Cancers	GDSC	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1389
p.A271G	ACH-002091	Skin Cancer	CCLE	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1389
p.A271G	CAL-39	vulva	COSMIC	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1389
p.D191Y	SIDM01117	Small Cell Lung Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2222
p.D191Y	ACH-002176	Lung Cancer	CCLE	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2222
p.D191Y	NCI-H748	lung	COSMIC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2222
p.V208M	SIDM00589	Oral Cavity Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.V208M	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.V208M	SIDM01194	Hepatocellular Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.V208M	SIDM00238	Ovarian Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.V208M	SIDM00619	Thyroid Gland Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.V208M	SIDM00252	Biliary Tract Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.V208M	SIDM00242	Osteosarcoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.V208M	SIDM00274	Gastric Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.V208M	SIDM00604	Oral Cavity Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.V208M	SIDM00381	Cervical Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.V208M	SIDM01033	Bladder Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.V208M	SIDM01622	Breast Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.V208M	SIDM01469	Pancreatic Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.V208M	SIDM01494	Glioblastoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.A267D	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.25
p.A267D	ACH-001127	Leukemia	CCLE	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.25
p.A267D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PKTST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.25
p.T262P	SIDM00118	Colorectal Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	260:264	Mutation altering degron motif	0.7031
p.T262P	ACH-001081	Colon/Colorectal Cancer	CCLE	PKTST	DEG_SPOP_SBC_1	260:264	Mutation altering degron motif	0.7031
p.T262P	HCC2998	large intestine	COSMIC	PKTST	DEG_SPOP_SBC_1	260:264	Mutation altering degron motif	0.7031
p.M193L	SIDM00976	Melanoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2778
p.M193L	ACH-002205	Skin Cancer	CCLE	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2778
p.M193L	WM1552C	skin	COSMIC	MPVFQE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GARIN4

UniProt ID: Q8IYT1

Entrez ID: 149647

Protein name: Golgi associated RAB2 interactor protein 4 (Golgi-associated Rab2B interactor-like 4) (GARI-L4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GARIN4 in