DegronMD

Uniprot ID: Q8IYT1

Source protein: Golgi associated RAB2 interactor protein 4

Source gene: GARIN4

Class: LIG_APCC_ABBA_1

Location: 195:200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6453

ASA_SCORE: 76.9

COIL: 0.554

CONS_SCORE: 0.6008

DSS_SCORE: 0.3494

HELIX: 0.3328

FCONS_SCORE: 1.0654

RIG_SCORE: 0.8611

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P188Q	TCGA-BT-A20N	BLCA	TCGA	MPVFQE	LIG_APCC_ABBA_1	0.1389
p.P188Q	DO550	BLCA	ICGC	MPVFQE	LIG_APCC_ABBA_1	0.1389
p.G206R	TCGA-EE-A20C	SKCM	TCGA	MPVFQE	LIG_APCC_ABBA_1	0.1667
p.G206R	DO222775	MELA	ICGC	MPVFQE	LIG_APCC_ABBA_1	0.1667
p.G206R	DO47665	SKCM	ICGC	MPVFQE	LIG_APCC_ABBA_1	0.1667
p.M195I	TCGA-LN-A49V	ESCA	TCGA	MPVFQE	LIG_APCC_ABBA_1	0.6507
p.P188T	TCGA-NJ-A55R	LUAD	TCGA	MPVFQE	LIG_APCC_ABBA_1	0.1389
p.P188T	DO218947	LUAD	ICGC	MPVFQE	LIG_APCC_ABBA_1	0.1389
p.S204R	SIDM01137	Pancreatic Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.2222
p.S204R	ACH-000235	Pancreatic Cancer	CCLE	MPVFQE	LIG_APCC_ABBA_1	0.2222
p.S204R	PANC-04-03	pancreas	COSMIC	MPVFQE	LIG_APCC_ABBA_1	0.2222
p.D191Y	SIDM01117	Small Cell Lung Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.2222
p.D191Y	ACH-002176	Lung Cancer	CCLE	MPVFQE	LIG_APCC_ABBA_1	0.2222
p.D191Y	NCI-H748	lung	COSMIC	MPVFQE	LIG_APCC_ABBA_1	0.2222
p.V208M	SIDM00589	Oral Cavity Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.1111
p.V208M	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.1111
p.V208M	SIDM01194	Hepatocellular Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.1111
p.V208M	SIDM00238	Ovarian Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.1111
p.V208M	SIDM00619	Thyroid Gland Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.1111
p.V208M	SIDM00252	Biliary Tract Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.1111
p.V208M	SIDM00242	Osteosarcoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.1111
p.V208M	SIDM00274	Gastric Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.1111
p.V208M	SIDM00604	Oral Cavity Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.1111
p.V208M	SIDM00381	Cervical Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.1111
p.V208M	SIDM01033	Bladder Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.1111
p.V208M	SIDM01622	Breast Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.1111
p.V208M	SIDM01469	Pancreatic Carcinoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.1111
p.V208M	SIDM01494	Glioblastoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.1111
p.M193L	SIDM00976	Melanoma	GDSC	MPVFQE	LIG_APCC_ABBA_1	0.2778
p.M193L	ACH-002205	Skin Cancer	CCLE	MPVFQE	LIG_APCC_ABBA_1	0.2778
p.M193L	WM1552C	skin	COSMIC	MPVFQE	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MPVFQE

Degron related mutations and impact score

Drug responses associated with GARIN4 mutations

All proteins holding degron of MPVFQE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYT1	Golgi associated RAB2 interactor protein 4	LIG_APCC_ABBA_1	195:200	MPVFQE	APC,CDC20,FZR1	0.6453	More...