DegronMD

Uniprot ID: Q8IYT1

Source protein: Golgi associated RAB2 interactor protein 4

Source gene: GARIN4

Class: DEG_SPOP_SBC_1

Location: 260:264

E3 ligase: SPOP

DEGRON score: 0.961

ASA_SCORE: 86.58

COIL: 0.85

CONS_SCORE: 0.363

DSS_SCORE: 0.5301

HELIX: 0.1148

FCONS_SCORE: 1.1462

RIG_SCORE: 0.7494

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P270T	TCGA-55-8089	LUAD	TCGA	PKTST	DEG_SPOP_SBC_1	0.1667
p.P270T	DO23690	LUAD	ICGC	PKTST	DEG_SPOP_SBC_1	0.1667
p.A257V	TCGA-67-3771	LUAD	TCGA	PKTST	DEG_SPOP_SBC_1	0.25
p.A257V	DO25797	LUAD	ICGC	PKTST	DEG_SPOP_SBC_1	0.25
p.T272I	TCGA-D1-A103	UCEC	TCGA	PKTST	DEG_SPOP_SBC_1	0.1111
p.T272I	DO42312	UCEC	ICGC	PKTST	DEG_SPOP_SBC_1	0.1111
p.N256S	TCGA-DD-AACP	LIHC	TCGA	PKTST	DEG_SPOP_SBC_1	0.2222
p.N256S	DO52210	LIHC	ICGC	PKTST	DEG_SPOP_SBC_1	0.2222
p.P260S	TCGA-F5-6814	READ	TCGA	PKTST	DEG_SPOP_SBC_1	0.6752
p.P260S	DO36556	READ	ICGC	PKTST	DEG_SPOP_SBC_1	0.6752
p.S258F	TCGA-FW-A3R5	SKCM	TCGA	PKTST	DEG_SPOP_SBC_1	0.2778
p.S258F	DO37406	SKCM	ICGC	PKTST	DEG_SPOP_SBC_1	0.2778
p.N253S	DO229010	COCA	ICGC	PKTST	DEG_SPOP_SBC_1	0.1389
p.A271G	SIDM00935	Other Solid Cancers	GDSC	PKTST	DEG_SPOP_SBC_1	0.1389
p.A271G	ACH-002091	Skin Cancer	CCLE	PKTST	DEG_SPOP_SBC_1	0.1389
p.A271G	CAL-39	vulva	COSMIC	PKTST	DEG_SPOP_SBC_1	0.1389
p.A267D	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PKTST	DEG_SPOP_SBC_1	0.25
p.A267D	ACH-001127	Leukemia	CCLE	PKTST	DEG_SPOP_SBC_1	0.25
p.A267D	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PKTST	DEG_SPOP_SBC_1	0.25
p.T262P	SIDM00118	Colorectal Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	0.7031
p.T262P	ACH-001081	Colon/Colorectal Cancer	CCLE	PKTST	DEG_SPOP_SBC_1	0.7031
p.T262P	HCC2998	large_intestine	COSMIC	PKTST	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70Z35	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein	DEG_SPOP_SBC_1	948:952	PKTST	SPOP	0.9793	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	41:45	PKTST	SPOP	0.9606	More...
Q96NE9	FERM domain-containing protein 6	DEG_SPOP_SBC_1	534:538	PKTST	SPOP	0.7639	More...
Q9BW04	Specifically androgen-regulated gene protein	DEG_SPOP_SBC_1	503:507	PKTST	SPOP	0.5589	More...
Q8IYT1	Golgi associated RAB2 interactor protein 4	DEG_SPOP_SBC_1	260:264	PKTST	SPOP	0.961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons