DegronMD - Q70Z35(PREX2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T950I	TCGA-33-4587	LUSC	TCGA	PKTST	DEG_SPOP_SBC_1	948:952	Mutation altering degron motif	0.7078
p.T950I	DO27683	LUSC	ICGC	PKTST	DEG_SPOP_SBC_1	948:952	Mutation altering degron motif	0.7078
p.E944K	TCGA-D3-A5GO	SKCM	TCGA	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.2222
p.E944K	DO47419	SKCM	ICGC	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.2222
p.G955R	TCGA-D3-A5GU	SKCM	TCGA	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.25
p.G955R	DO229453	SKCA	ICGC	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.25
p.G955R	DO47584	SKCM	ICGC	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.25
p.H939Y	TCGA-EE-A29G	SKCM	TCGA	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.0833
p.H939Y	DO47303	SKCM	ICGC	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.0833
p.S953Y	TCGA-H4-A2HO	BLCA	TCGA	PKTST	DEG_SPOP_SBC_1	948:952	Mutation blocking phosphorylation signal	0.75
p.S953Y	DO494	BLCA	ICGC	PKTST	DEG_SPOP_SBC_1	948:952	Mutation blocking phosphorylation signal	0.75
p.V945G	TCGA-V5-AASX	ESCA	TCGA	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.25
p.A957T	DO233156	GACA	ICGC	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.1944
p.A957T	SIDM00534	Colorectal Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.1944
p.A957T	ACH-000986	Colon/Colorectal Cancer	CCLE	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.1944
p.A957T	HT-115	large intestine	COSMIC	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.1944
p.N941S	DO233625	GACA	ICGC	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.1389
p.T952N	DO23234	LINC	ICGC	PKTST	DEG_SPOP_SBC_1	948:952	Mutation altering degron motif	0.8166
p.C938F	SIDM00839	Colorectal Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.0556
p.C938F	ACH-000950	Colon/Colorectal Cancer	CCLE	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.0556
p.C938F	LoVo	large intestine	COSMIC	PKTST	DEG_SPOP_SBC_1	948:952	Mutation rewiring degron network	0.0556

Kaplan plot for PREX2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PREX2

UniProt ID: Q70Z35

Entrez ID: 80243

Protein name: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PREX2 in