DegronMD

Uniprot ID: Q70Z35

Source protein: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

Source gene: PREX2

Class: DEG_SPOP_SBC_1

Location: 948:952

E3 ligase: SPOP

DEGRON score: 0.9793

ASA_SCORE: 78.66

COIL: 0.6734

CONS_SCORE: 0.4054

DSS_SCORE: 0.3216

HELIX: 0.0572

FCONS_SCORE: 0.8615

RIG_SCORE: 0.7357

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T950I	TCGA-33-4587	LUSC	TCGA	PKTST	DEG_SPOP_SBC_1	0.7078
p.T950I	DO27683	LUSC	ICGC	PKTST	DEG_SPOP_SBC_1	0.7078
p.E944K	TCGA-D3-A5GO	SKCM	TCGA	PKTST	DEG_SPOP_SBC_1	0.2222
p.E944K	DO47419	SKCM	ICGC	PKTST	DEG_SPOP_SBC_1	0.2222
p.G955R	TCGA-D3-A5GU	SKCM	TCGA	PKTST	DEG_SPOP_SBC_1	0.25
p.G955R	DO229453	SKCA	ICGC	PKTST	DEG_SPOP_SBC_1	0.25
p.G955R	DO47584	SKCM	ICGC	PKTST	DEG_SPOP_SBC_1	0.25
p.H939Y	TCGA-EE-A29G	SKCM	TCGA	PKTST	DEG_SPOP_SBC_1	0.0833
p.H939Y	DO47303	SKCM	ICGC	PKTST	DEG_SPOP_SBC_1	0.0833
p.S953Y	TCGA-H4-A2HO	BLCA	TCGA	PKTST	DEG_SPOP_SBC_1	0.75
p.S953Y	DO494	BLCA	ICGC	PKTST	DEG_SPOP_SBC_1	0.75
p.V945G	TCGA-V5-AASX	ESCA	TCGA	PKTST	DEG_SPOP_SBC_1	0.25
p.A957T	DO233156	GACA	ICGC	PKTST	DEG_SPOP_SBC_1	0.1944
p.A957T	SIDM00534	Colorectal Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	0.1944
p.A957T	ACH-000986	Colon/Colorectal Cancer	CCLE	PKTST	DEG_SPOP_SBC_1	0.1944
p.A957T	HT-115	large_intestine	COSMIC	PKTST	DEG_SPOP_SBC_1	0.1944
p.N941S	DO233625	GACA	ICGC	PKTST	DEG_SPOP_SBC_1	0.1389
p.T952N	DO23234	LINC	ICGC	PKTST	DEG_SPOP_SBC_1	0.8166
p.C938F	SIDM00839	Colorectal Carcinoma	GDSC	PKTST	DEG_SPOP_SBC_1	0.0556
p.C938F	ACH-000950	Colon/Colorectal Cancer	CCLE	PKTST	DEG_SPOP_SBC_1	0.0556
p.C938F	LoVo	large_intestine	COSMIC	PKTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70Z35	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein	DEG_SPOP_SBC_1	948:952	PKTST	SPOP	0.9793	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	41:45	PKTST	SPOP	0.9606	More...
Q96NE9	FERM domain-containing protein 6	DEG_SPOP_SBC_1	534:538	PKTST	SPOP	0.7639	More...
Q9BW04	Specifically androgen-regulated gene protein	DEG_SPOP_SBC_1	503:507	PKTST	SPOP	0.5589	More...
Q8IYT1	Golgi associated RAB2 interactor protein 4	DEG_SPOP_SBC_1	260:264	PKTST	SPOP	0.961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons