DegronMD

Uniprot ID: Q9BW04

Source protein: Specifically androgen-regulated gene protein

Source gene: SARG

Class: DEG_APCC_DBOX_1

Location: 589:597

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9491

ASA_SCORE: 70.2222

COIL: 0.2239

CONS_SCORE: 0.9299

DSS_SCORE: 0.6004

HELIX: 0.7764

FCONS_SCORE: 1.2285

RIG_SCORE: 0.7839

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L593P	TCGA-91-6831	LUAD	TCGA	RREALKKLG	DEG_APCC_DBOX_1	0.7582
p.L593P	DO23753	LUAD	ICGC	RREALKKLG	DEG_APCC_DBOX_1	0.7582
p.L596P	TCGA-B5-A3FA	UCEC	TCGA	RREALKKLG	DEG_APCC_DBOX_1	0.7582
p.L596P	DO52402	UCEC	ICGC	RREALKKLG	DEG_APCC_DBOX_1	0.7582
p.R589I	TCGA-EY-A1G8	UCEC	TCGA	RREALKKLG	DEG_APCC_DBOX_1	0.6991
p.R589I	DO43578	UCEC	ICGC	RREALKKLG	DEG_APCC_DBOX_1	0.6991
p.G597V	DO223074	ESCA	ICGC	RREALKKLG	DEG_APCC_DBOX_1	0.6421
p.E591K	DO222880	MELA	ICGC	RREALKKLG	DEG_APCC_DBOX_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BW04	Specifically androgen-regulated gene protein	DEG_APCC_DBOX_1	589:597	RREALKKLG	APC,CDC20,FZR1	0.9491	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons