DegronMD

Uniprot ID: Q9BW04

Source protein: Specifically androgen-regulated gene protein

Source gene: SARG

Class: DEG_SCF_FBW7_1

Location: 230:236

E3 ligase: FBXW7

DEGRON score: 0.9109

ASA_SCORE: 87.0571

COIL: 0.9109

CONS_SCORE: 0.3407

DSS_SCORE: 0.929

HELIX: 0.0563

FCONS_SCORE: 0.8625

RIG_SCORE: 0.5432

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E240Q	TCGA-39-5022	LUSC	TCGA	LHTPSSS	DEG_SCF_FBW7_1	0.2222
p.E240Q	DO27604	LUSC	ICGC	LHTPSSS	DEG_SCF_FBW7_1	0.2222
p.S234C	TCGA-50-5946	LUAD	TCGA	LHTPSSS	DEG_SCF_FBW7_1	0.643
p.S234C	DO24556	LUAD	ICGC	LHTPSSS	DEG_SCF_FBW7_1	0.643
p.S236P	TCGA-59-2352	OV	TCGA	LHTPSSS	DEG_SCF_FBW7_1	0.6752
p.S236P	DO28068	OV	ICGC	LHTPSSS	DEG_SCF_FBW7_1	0.6752
p.S235N	TCGA-EO-A3AV	UCEC	TCGA	LHTPSSS	DEG_SCF_FBW7_1	0.5958
p.S235N	DO52412	UCEC	ICGC	LHTPSSS	DEG_SCF_FBW7_1	0.5958
p.S235N	SIDM00879	Breast Carcinoma	GDSC	LHTPSSS	DEG_SCF_FBW7_1	0.5958
p.S235N	SIDM00954	Breast Carcinoma	GDSC	LHTPSSS	DEG_SCF_FBW7_1	0.5958
p.S235N	SIDM00257	Neuroblastoma	GDSC	LHTPSSS	DEG_SCF_FBW7_1	0.5958
p.S244L	TCGA-IR-A3LK	CESC	TCGA	LHTPSSS	DEG_SCF_FBW7_1	0.1111
p.S244L	DO44299	CESC	ICGC	LHTPSSS	DEG_SCF_FBW7_1	0.1111
p.H231Y	TCGA-WE-AAA0	SKCM	TCGA	LHTPSSS	DEG_SCF_FBW7_1	0.6118
p.H231Y	DO51294	SKCM	ICGC	LHTPSSS	DEG_SCF_FBW7_1	0.6118
p.G220E	DO228750	GACA	ICGC	LHTPSSS	DEG_SCF_FBW7_1	0.0556
p.G220V	DO233732	GACA	ICGC	LHTPSSS	DEG_SCF_FBW7_1	0.0556
p.P233Q	DO229035	LICA	ICGC	LHTPSSS	DEG_SCF_FBW7_1	0.7035
p.E238K	DO222868	MELA	ICGC	LHTPSSS	DEG_SCF_FBW7_1	0.2778
p.E238K	SIDM00190	Melanoma	GDSC	LHTPSSS	DEG_SCF_FBW7_1	0.2778
p.E238K	ACH-002097	Skin Cancer	CCLE	LHTPSSS	DEG_SCF_FBW7_1	0.2778
p.T225A	ACH-000978	Endometrial/Uterine Cancer	CCLE	LHTPSSS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BW04	Specifically androgen-regulated gene protein	DEG_SCF_FBW7_1	230:236	LHTPSSS	FBXW7	0.9109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons