DegronMD - O75444(MAF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V67A	TCGA-AP-A0LM	UCEC	TCGA	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1944
p.V67A	DO43306	UCEC	ICGC	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1944
p.G53D	TCGA-BR-4361	STAD	TCGA	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2778
p.G53D	DO38887	STAD	ICGC	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2778
p.S65N	TCGA-IB-7651	PAAD	TCGA	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.25
p.S65N	DO46657	PAAD	ICGC	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.25
p.T58P	TCGA-Z2-A8RT	SKCM	TCGA	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.7031
p.T58P	DO51301	SKCM	ICGC	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.7031
p.P69L	DO222496	COCA	ICGC	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1389
p.A51T	DO234462	ESAD	ICGC	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2222
p.A51T	SIDM00945	Colorectal Carcinoma	GDSC	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2222
p.A51T	ACH-000895	Colon/Colorectal Cancer	CCLE	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2222
p.A51T	CL-34	large intestine	COSMIC	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2222
p.P68T	DO229015	LICA	ICGC	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1667
p.T58N	DO229035	LICA	ICGC	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.7055
p.S70F	DO229072	PRAD	ICGC	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation blocking phosphorylation signal	0.5556
p.P71L	SIDM00608	Plasma Cell Myeloma	GDSC	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0833
p.P71L	ACH-000714	Myeloma	CCLE	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0833
p.S66P	SIDM01519	Head and Neck Carcinoma	GDSC	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2222
p.S66P	ACH-000992	Head and Neck Cancer	CCLE	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2222
p.G53R	ACH-000402	Lymphoma	CCLE	LSSTPMST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2778

Kaplan plot for MAF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAF

UniProt ID: O75444

Entrez ID: 4094

Protein name: Transcription factor Maf (Proto-oncogene c-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAF in